Original Article

Distribution of pancreas imaging agents with 11C-amino acids in mice

Qi-xun SUN, Qian-mai JI, Yong-chuan WANG, De-feng XIE, Xi-chang SHI, Yi-fang YE, Zhen-tang ZHOU, Yun WANG, Ruo-ling HUA, Sheng-yang CHEN, Fa-sheng FAN, Chai-jie GU, Liu-fang ZHANG, Yong-jian LI, Hai-qiu BAO, Wei-yu HE

Abstract

11CO and 11CO2 were prepared through 11B(P,n)11C reaction and catalyzed to form Na11CN, from which [11C] valine,[ 11C] leucine and [11C] cycloleucine were synthesized. These 3 amino acids were injected iv 10 μCi/mouse of ICR strain. At 30 min the uptake rate was highest in pancreas which was3-10 times that of other organs.
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