Drug enzyme induction of antiepilepsirine in mice and rats

Antiepilepsirine, 3,4 methylene dioxycinnamoyl piperidine, is a new antiepileptic drug. It has been found that the plasma level of phenytoin in epileptic patients during the treatment of phenytoin in combination with antiepilepsirine seemed to be lower than that in the patients only receving phenytoin. Antiepilepsirine and Phenobarbital decreased the aneasthetic effect of sodium thiopental and the plasma concentration of plenytoin in mice and rats. An increase of cytochrome P-450 in liver homogenates induced by antiepilepsirine and Phenobarbital in mice and rats was showed. The concentrations of cytochrome P-450 in liver homogenates in mice of control group, antiepilepsirine-treated group and Phenobarbital-treated group were 33±5, 48±7 and 70±7nmol/g, respectively. In rats, the concentrations of cytochrome P-450 in the 3 groups were 44±5, 67±15 and 110±15 nmol/g, respectively. It is suggested that antiepilepsirine exhibits a weaker drug enzyme induction in liver homogenates than Phenobarbital does.