Original Articles

Mutagenicity of a new antimalarial drug, pyronaridine, in the Salmonella/microsome system

Authors: Yi-chang Ni, Yue-qin Xu, Bao-ruo Shao

Abstract

The mutagenic activity of a new antimalarial drug, pyronaridine, was studied on 5 histidine-requiring strains of Salmonella typhimurium (TA100, TA98, TA1535, TA1537 and TA1538) with and without S-9, using the plate test.
After the rats had been induced by PCB, S-9 were isolated from the livers. Two antiparasitic drugs with known mutagenicity, hycanthone and furapromide, were used as positive controls.
In strain TA1537, pyronaridine induced mutations without S-9 at the doses of 100-1000 μg/plate. The His+ revertants per plate increased dose-dependently. Pyronaridine did not induce mutations of other 4 strains.
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