Original Articles

Interaction of seven 3-methyl fentanyl compounds with cerebroside sulfate

De-he Zhou, Zhi-yi Li, Chong-hu Ni, Zhi-qiang Chi


Cerebroside sulfate (CS) was isolated and identified from pig brain. It was bound to [3H]naloxone with high affinity. The dissociation constant was 8.5*10(-8) M (20 degrees). Displacement potencies of fentanyl compounds, synthesized in our Institute, correlated significantly with their analgesic potencies. The CS may be an important component of receptor of 8-methyl fentanyl compounds. The results supported the hypothesis that CS may be a component of the opiate receptor.

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