Original Articles

Antineoplastic action of triptolide and its effect on the immunologic functions in mice

Tan-mu Zhang, Zheng-yu Chen, Chen Lin


Triptolide, isolated from Tripterygium hypoglaucum, 0.2 and 0.25 mg/kg injected ip markedly prolonged the survival time of L615-bearing mice, and some mice survived more than a month. The long survivors were rechallanged with leukemic cells, but no disease was induced thereafter.
The hemolysin test was used to monitor the function of humoral mediated immunity and the graft versus host reaction and tumor-concomitant immunity were used to monitor the function of the cell-mediated immunity. Triptolide (0.2 and 0.25 mg/kg ip) had a depressant effect on the humoral mediated immunity and no effect on the cell-mediated immunity.

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