Original Articles

Anti-histamine action of nikethamide

Jian-zhong Ma, Ling-di Ma, Xiao-ying Sun


The contractile responses of histamine on isolated ileum of guinea-pig were antagonized by nikethamide. The pA2=4.15 (95% confidence limits 3.75-4.55). Nikethamide antagonized the contractile effect induced by histamine in isolated tracheas smooth muscle preparation of guinea-pig. On isolated guinea-pig right atria, nikethamide antagonized the increase of beating rate induced by histamine.

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