Cardiovascular effects of sodium selenite
Abstract
Effects of Na2SeO3 were studied on 76 anesthetized dogs.
1. A single iv of 0.5 mg/kg caused a significant decrease of blood pressure, while 2 mg/kg caused a more obvious hypotensive effect.
2. The heart rate was not influenced by 1 mg/kg, but was decreased markedly by 2 mg/kg.
3. The left ventricular work did not show marked changes after 1 mg/kg, but was depressed after 2 mg/kg.
4. IV 1.5 or 2.0 mg/kg diminished the carotid artery and femoral artery blood flows.
5. No significant changes were seen in aortic blood flow and coronary sinus flow after iv 0.5, 1, 2 mg/kg.
6. The pressor responses induced by hypoxia or by pituitrin could be lessened by Na2SeO3.
7. The survival time of the mice under hypoxia was prolonged by pretreatment with ip Na2SeO3 0.2-1.5 mg/kg.
Keywords:
1. A single iv of 0.5 mg/kg caused a significant decrease of blood pressure, while 2 mg/kg caused a more obvious hypotensive effect.
2. The heart rate was not influenced by 1 mg/kg, but was decreased markedly by 2 mg/kg.
3. The left ventricular work did not show marked changes after 1 mg/kg, but was depressed after 2 mg/kg.
4. IV 1.5 or 2.0 mg/kg diminished the carotid artery and femoral artery blood flows.
5. No significant changes were seen in aortic blood flow and coronary sinus flow after iv 0.5, 1, 2 mg/kg.
6. The pressor responses induced by hypoxia or by pituitrin could be lessened by Na2SeO3.
7. The survival time of the mice under hypoxia was prolonged by pretreatment with ip Na2SeO3 0.2-1.5 mg/kg.