Review Article

Gut microbiota in pancreatic diseases: possible new therapeutic strategies

Li-long Pan1, Bin-bin Li2,3, Xiao-hua Pan2,3, Jia Sun2,3
1 School of Medicine, Jiangnan University, Wuxi 214122, China
2 State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China
3 School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Correspondence to: Jia Sun:,
DOI: 10.1038/s41401-020-00532-0
Received: 6 July 2020
Accepted: 8 September 2020
Advance online: 22 October 2020


Pancreatic diseases such as pancreatitis, type 1 diabetes and pancreatic cancer impose substantial health-care costs and contribute to marked morbidity and mortality. Recent studies have suggested a link between gut microbiota dysbiosis and pancreatic diseases; however, the potential roles and mechanisms of action of gut microbiota in pancreatic diseases remain to be fully elucidated. In this review, we summarize the evidence that supports relationship between alterations of gut microbiota and development of pancreatic diseases, and discuss the potential molecular mechanisms of gut microbiota dysbiosis in the pathogenesis of pancreatic diseases. We also propose current strategies toward gut microbiota to advance a developing research field that has clinical potential to reduce the cost of pancreatic diseases.
Keywords: gut microbiota; pancreatic diseases; type 1 diabetes; acute pancreatitis; chronic pancreatitis; pancreatic cancer

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