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Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery

Authors: Di Sun1, Shi-yan Guo2, Li Yang1, Ya-ru Wang1, Xiao-hui Wei1, Sha Song2, Yi-wei Yang2, Yong Gan2, Zheng-tao Wang1
1 The MOE Key Laboratory of Standardization of Chinese Medicine and Shanghai Key Laboratory of Compound Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China
Correspondence to: Zheng-tao Wang: ztwang@shutcm.edu.cn,
DOI: 10.1038/s41401-019-0288-7
Received: 18 April 2019
Accepted: 11 July 2019
Advance online: 18 September 2019

Abstract

Inefficient diabetic ulcer healing and scar formation remain a challenge worldwide, owing to a series of disordered and dynamic biological events that occur during the process of healing. A functional wound dressing that is capable of promoting ordered diabetic wound recovery is eagerly anticipated. In this study, we designed a silicone elastomer with embedded 20(S)-protopanaxadiol-loaded nanostructured lipid carriers (PPD-NS) to achieve ordered recovery in scarless diabetic ulcer healing. The nanostructured lipid carriers were prepared through an emulsion evaporation-solidification method and then incorporated into a network of silicone elastomer to form a unique nanostructured lipid carrier-enriched gel formulation. Interestingly, the PPD-NS showed excellent in vitro anti-inflammatory and proangiogenic activity. Moreover, in diabetic mice with full-thickness skin excision wound, treatment with PPD-NS significantly promoted in vivo scarless wound healing through suppressing inflammatory infiltration in the inflammatory phase, promoting angiogenesis during the proliferation phase, and regulating collagen deposition in the remodeling phase. Hence, this study demonstrates that the developed PPD-NS could facilitate ordered diabetic wound recovery via multifunctional improvement during different wound-healing phases. This novel approach could be promising for scarless diabetic wound healing.
Keywords: diabetic ulcer; ordered recovery; scarless wound healing; 20 (S)-protopanaxadiol; nanostructured lipid carrier; silicone elastomer

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