Vol 46, No 12 (December 2025): Acta Pharmacologica Sinica

Review Article

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an update   Pages (3129-3142) Open
Wei-long Wu, Xiao-xi Gong, Zheng-hong Qin, Yan Wang
Peptide-MHC I regulatory mechanisms and intervention strategies in anti-tumor T cell immunity   Pages (3143-3153)
Zhi-chao Zhang, Ying Shen, Yu-shen Lin, Bo Yang, Ji Cao, Jun Li, Wen-bin Zhao
Metabolic enzyme-associated protein-protein interactions (mPPIs) in cancer: potential vulnerability for cancer treatment?   Pages (3154-3162)
Yu-ting Tang, Tian-yi Chen, Zi-yi Liu, Ming-yu Luo, Miao-miao Gong, Ying Shen

Article

A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations   Pages (3163-3176) Open
Zhi-bin Hu, Wei-tang Liu, Yi-wei Li, Ling Hu, Ying Huang, Xi-yue Liu, Qiong Zhang, Yu-bing Wang, Jia-yin Chen, Ze-xuan Li, Si-xin Tu, Li Zhao, Ning-ning Song, Oded Klavir, Yu-qiang Ding
G-protein coupled receptor kinase 2 mediates rheumatoid arthritis-induced depression-like behaviors via the hippocampal CRHR1 signaling pathway   Pages (3177-3189)
Qian Meng, Meng-hui Guo, Rui Zhang, Jing Wei, Qian Chen, Xue-chun Zhao, Cai-qi Xu, Yao-yao Wu, Jia-jie Kuai, Jie-min Zhao, Yu-jing Wu, Chong-huan Ye, Hong-rui Wei, Xia Zhu, Yan Jin, Zhi Zhang, Wei Wei
Exploring the distinct activation mechanisms of neuromedin B receptor through multiple replica molecular dynamics simulations and Markov state modeling   Pages (3190-3203)
Nuan Li, Ming-yuan Yang, Ming-yang Zhang, Ning Liu, Ai-wu Zhou, Zong-tao Chai, Shao-yong Lu
PYRCR alleviates myocardial ischemia/reperfusion injury in mice via inhibiting DRG2-mediated cardiomyocyte pyroptosis   Pages (3204-3216)
Xin-zhe Chen, Hong-fei Xu, Xue-mei Zhao, Fu-hai Li, Jia-hao Ren, Lu-yu Zhou, Cui-yun Liu, Yu-qin Wang, Su-min Yang, Fang Liu, Yu-hui Zhang, Kun Wang, Xiang-qian Gao
PHB2 protects against pressure overload-induced myocardial remodeling in mice via stabilizing TOMM40 and regulating mitochondrial morphofunctional homeostasis   Pages (3217-3229)
Dan Li, Jia-hao Li, Ying-ying Guo, Ya-jie Chen, Meng Zhang, Fei-xue Xu, Wan-yi Li, Qi-zhu Tang
Gut microbiota-derived butyrate prevents aortic dissection via GPR41   Pages (3230-3243)
Huan-xin Yang, Bing-xin Wang, Xiao-liang Dong, Jia Sun, Zeng-li Miao, Li-long Pan
Serum amyloid A3 aggravates bleomycin-induced pulmonary fibrosis through Krüppel-like factor 6-dependent interlukin-36α expression   Pages (3244-3256)
Xin-yi Yang, Ying Liu, Wen Li, Hui-xing Li, Yu-wen Zhong, Yu-han Cao, Tian-yi Liu, A-jing Xu, Wei Gu, Qing Liang, Feng Qian, Lei Sun
Senkyunolide A ameliorates cholestatic liver fibrosis by controlling CLCC1-mediated endoplasmic reticulum Ca2+ release   Pages (3257-3272)
Ya-jing Li, Meng-yu Guo, Wen-qing Qin, Jia-nan Li, Yu-fei Li, Fu-kun Zhang, Xiao-yong Xue, Shuo Li, Jiao-rong Qu, Run-ping Liu, Lei Wang, Xiao-jiao-yang Li
Ginsenoside (20)S-APPT induces ferroptosis in hepatocellular carcinoma and cholangiocarcinoma by targeting FSP1   Pages (3273-3290)
Fan-yu Liu, Yuan-jie Yang, Xue-long Wang, Yan Hong, Xiao-peng Ou-Yang, Lu Chang, Nan-lin Zhu, Ao Huang, Min-min Zhang, Jia Liu, Mei-yu Geng, Ai-jun Shen
Somatostatin receptor 2 targeting peptide modifications for peptide-drug conjugate treatment of small cell lung cancer   Pages (3291-3301)
Qing Bo, Meng-ge Zhang, Fan Yang, Yong Zheng, Ze-lin Li, Yan-min Zheng, Fang-ming Wu, Jun Liang, Li Zhou, Dong-sheng Li, Yun Wu, Chang-lin Tian, Pei Lv, Pan Shi
Identification of AKOS, a Chikungunya virus inhibitor, as a USP14 inhibitor for colorectal cancer treatment   Pages (3302-3313)
Bin Lu, Yi-yun Sun, Jia-hao Zhou, Dan-ni Chen, Yue Guo, Yu-lu Chen, Cheng-hao Pan, Zheng-yang Chen, Qiao-jun He, Meng Yuan, Ji Cao, Li Jiang, Bo Yang
Co-delivery of shikonin and JQ1 inhibits triple-negative breast tumor progression and lung metastasis through inhibition of epithelial-mesenchymal transition and vasculogenic mimicry   Pages (3314-3326)
Xing-yu Xu, Dipika Ramdas Kalambhe, Yue Yu, Ling-xi Yu, Zhi-wen Gu, Xiao-ying Jin, Hui-yuan Wang, Yong-zhuo Huang
Receptor tyrosine kinase inhibitor tivozanib regulates cell state plasticity and restores MITF dependency in BRAF wild-type melanoma   Pages (3327-3342)
Yan-ni Ma, Xu-hui Ma, Mei-ling Hao, Rui-xin Liu, Yang Zheng, Jie Yang, Xiang-yu Chen, Yi-nan Chen, Sheng-nan Zheng, Yan-jie Zhang, Ming Lei, Min Jiang, Wei Guo, Han-lin Zeng
Programmed sequential nanostructural conversion at nano-bio interface for synergistic cancer phototheranostics   Pages (3343-3354)
Shi Sun, Rui Wang, Xue-lu-er Mu, Wen-bi Feng, Hao Kong, Ya-jie Li, Min Gao, Ying-xi Lu, Hui-rui Sun, Xian-feng Zhou
An update for AlphaFold3 versus experimental structures: assessing the precision of small molecule binding in GPCRs   Pages (3355-3364)
Shi-yi Shen, Jun-rui Li, Yu-song Wang, Shao-ning Li, H. Eric Xu, Xin-heng He
SAAINT-DB: a comprehensive structural antibody database for antibody modeling and design   Pages (3365-3375)
Xiaoqiang Huang, Jun Zhou, Shuang Chen, Xiaofeng Xia, Y. Eugene Chen, Jie Xu
Uricolysis by Arthrobacter globiformis uricase: structural basis for its catalytic activity and thermostability   Pages (3376-3385)
Lu-nan Lv, Shi-jia Zu, Zhong-lian Cao, Xiao-qin Huang, Wei Fu

Brief Communication

SERCA2 regulates Piezo1 channel activation and contributes to the cardiac function and baroreflex in mice   Pages (3386-3395)
Jia-xin Zhao, Yin-zhi Xu, Hui-xiao Fu, Jia-qun Li, Mao Yue, Zhao-yuan Xu, Xue-lian Li, Chang-peng Cui, Bai-yan Li

Correspondence

Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation   Pages (3396-3398)
Mei-jie Chen, Zhi-dan Zhang, Fan-shun Zhang, Paul C. Evans, Hans Strijdom, Suo-wen Xu