Isoginkgetin, a natural biflavonoid from Ginkgo biloba, inhibits inflammatory response in endothelial cells via suppressing NF-κB activation
Mei-jie Chen1,
Zhi-dan Zhang1,
Fan-shun Zhang1,
Paul C. Evans2,
Hans Strijdom3,
Suo-wen Xu1,4
1 Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
2 William Harvey Research Institute, Barts and The London Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK
3 Centre for Cardio-metabolic Research in Africa, Division of Medical Physiology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
4 Anhui Provincial Key Laboratory of Metabolic Health and Panvascular Diseases, Hefei 230001, China
Correspondence to: Suo-wen Xu: sxu1984@ustc.edu.cn,
DOI: 10.1038/s41401-025-01612-9
Received: 8 April 2025
Accepted: 10 June 2025
Advance online: 16 July 2025
Abstract
Isoginkgetin (ISOGK), a naturally occurring biflavonoid first isolated from Ginkgo biloba leaves in 1983, is a member of the biflavonoid subclass characterized by two acacetin monomers linked by a 3’-8” carbon-carbon bond to form a dimeric structure.
Keywords:
Isoginkgetin
