Vol 46, No 5 (May 2025): Acta Pharmacologica Sinica

Review Article

New advances in novel pharmacotherapeutic candidates for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) between 2022 and 2024   Pages (1145-1155)
Shu Wei Wong, Yong-yu Yang, Hui Chen, Li Xie, Xi-zhong Shen, Ning-ping Zhang, Jian Wu
Therapeutic potential and pharmacological mechanisms of Traditional Chinese Medicine in gout treatment   Pages (1156-1176)
Jing-wen Guo, Guo-qiang Lin, Xin-yi Tang, Jia-ying Yao, Chen-guo Feng, Jian-ping Zuo, Shi-jun He

Article

Compound 38, a novel potent and selective antagonist of adenosine A2A receptor, enhances arousal in mice   Pages (1177-1189)
Hui Zhang, Wei-xiang Ma, Qiong Xie, Li-fang Bu, Ling-xi Kong, Ping-chuan Yuan, Rong-hui Zhou, Yong-hui Wang, Lei Wu, Chen-yu Zhu, Zhi-lin Wang, Jun Han, Zhi-li Huang, Yi-qun Wang
Electrophysiological characterization of human KCNT1 channel modulators and the therapeutic potential of hydroquinine and tipepidine in KCNT1 mutation-associated epilepsy mouse model   Pages (1190-1204)
Qing Guo, Jun Gan, En-ze Wang, Yu-ming Wei, Jie Xu, Yun Xu, Fei-fei Zhang, Meng Cui, Meng-xing Jia, Ming-jian Kong, Qiong-yao Tang, Zhe Zhang
Inhibition of CD36 ameliorates mouse spinal cord injury by accelerating microglial lipophagy   Pages (1205-1220)
Bei-ni Wang, An-yu Du, Xiang-hang Chen, Ting Huang, Abdullah Al Mamun, Ping Li, Si-ting Du, Yan-zheng Feng, Lin-yuan Jiang, Jie Xu, Yu Wang, Shuang-shuang Wang, Kwonseop Kim, Kai-liang Zhou, Yan-qing Wu, Si-wang Hu, Jian Xiao
Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p   Pages (1221-1235)
Hao Wang, Li Zhang, Wan-yue Yang, Xiao-yi Ji, An-qi Gao, Yi-hong Wei, Xin Ding, Yue Kang, Jian-hua Ding, Yi Fan, Ming Lu, Gang Hu
eIF4A1 exacerbates myocardial ischemia-reperfusion injury in mice by promoting nuclear translocation of transgelin/p53   Pages (1236-1249)
Dan-yang Li, Xiao-xi Hu, Zhong-rui Tian, Qi-wen Ning, Jiang-qi Liu, Ying Yue, Wei Yuan, Bo Meng, Jia-liang Li, Yang Zhang, Zhen-wei Pan, Yu-ting Zhuang, Yan-jie Lu
Semaglutide administration protects cardiomyocytes in db/db mice via energetic improvement and mitochondrial quality control   Pages (1250-1261)
Meng-yun Tian, Ji-qin Yang, Jin-chuan Hu, Shan Lu, Yong Ji
YTHDF3-mediated FLCN/cPLA2 axis improves cardiac fibrosis via suppressing lysosomal function   Pages (1262-1274)
Yue Zhang, Hong-tao Diao, Ming-yang Leng, Ying-zi Wu, Bing-ying Huang, Xu Li, Wen-yue Tang, Kai-li Wu, Hui-ling Tan, Liang Wang, Wen Lu, Ao Xiong, Xiao-qi Shao, Hai-hai Liang, Jiao Guo
JOSD2 inhibits angiotensin II-induced vascular remodeling by deubiquitinating and stabilizing SMAD7   Pages (1275-1288)
Si-rui Shen, Zhu-qi Huang, Yu-die Yang, Ji-bo Han, Zi-min Fang, Yue Guan, Jia-chen Xu, Ju-lian Min, Yi Wang, Gao-jun Wu, Zhong-xiang Xiao, Wu Luo, Zhou-qing Huang, Guang Liang
Endothelial Gsα deficiency promotes ferroptosis and exacerbates atherosclerosis in apolipoprotein E-deficient mice via the inhibition of NRF2 signaling   Pages (1289-1302)
Li-fan He, Lei Wang, Jing-wei Li, Xiao Xiong, Xiao-lin Yue, Pei-dong Yuan, Han-lin Lu, Jian-gang Gao, Fang-pu Yu, Min Chen, Lee S. Weinstein, Jian-min Yang, Cheng Zhang, Xiaoteng Qin, Wencheng Zhang
Dehydrocorydaline maintains the vascular smooth muscle cell contractile phenotype by upregulating Spta1   Pages (1303-1316) Open
Yuan-ye Dang, Cui Chen, Qiu-fen Wei, Li-feng Gao, Shun-chi Zhang, Yong-xian Li, Xiao-yan Dai
Deletion of smooth muscle ZFP36 promotes neointimal hyperplasia in mice   Pages (1317-1328)
Lei Wang, Li-fan He, Xiao Xiong, Zhi-nan Wu, Mi Tian, Guang-qing Cao, Hui-xia Lu, Xiao-ping Ji, Yan-ling Zhang, Pavel Kovarik, Wencheng Zhang, Yan Liu
Peptidoglycan isolated from the fruit of Lycium barbarum alleviates liver fibrosis in mice by regulating the TGF-β/Smad7 signaling and gut microbiota   Pages (1329-1344)
Ying-min Nie, Wan-qi Zhou, Ting Niu, Meng-fei Mao, Yu-xue Zhan, Yun Li, Kai-ping Wang, Mei-xia Li, Kan Ding
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells   Pages (1345-1360)
Ting-ting Yang, Ying Liu, Yu-ting Shao, Lin Li, Dan-dan Pan, Tao Wang, Zhen-zhou Jiang, Bao-jing Li, Si-tong Qian, Meng Yan, Xia Zhu, Cai Heng, Jun-jie Liu, Qian Lu, Xiao-xing Yin
Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation   Pages (1361-1374)
Xin Chen, Hao-yu Wang, Tao Yang, Kai-rong Zhang, Shu-yue Lei, Lu-yao Qi, Jian Wu, Chun-lan Feng, Rong Zhou, Hu Zhou, Wei Tang
Humanized dual-targeting antibody–drug conjugates specific to MET and RON receptors as a pharmaceutical strategy for the treatment of cancers exhibiting phenotypic heterogeneity   Pages (1375-1389) Open
Minghai Wang, Qi Ma, Sreedhar Reddy Suthe, Rachel E. Hudson, Jing-ying Pan, Constantinos Mikelis, Miao-jin Zhu, Zhi-gang Wu, Dan-rong Shi, Hang-ping Yao
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia   Pages (1390-1403) Open
Yu-jun Chen, Yu Zhao, Ming-yue Yao, Ya-fang Wang, Ming Ma, Cheng-cheng Yu, Hua-liang Jiang, Wu Wei, Jie Shen, Xiao-wei Xu, Cheng-ying Xie
Organoid modeling identifies USP3-AS1 as a novel promoter in colorectal cancer liver metastasis through increasing glucose-driven histone lactylation   Pages (1404-1418)
Jia-min Zhou, Wei-xing Dai, Ren-jie Wang, Wei-qi Xu, Zhen Xiang, Yi-xiu Wang, Ti Zhang, Yi-ming Zhao, Lu Wang, An-rong Mao
Genome-wide CRISPR-Cas9 screening identifies ITGA8 responsible for abivertinib sensitivity in lung adenocarcinoma   Pages (1419-1432)
Xuan-guang Li, Guang-sheng Zhu, Pei-jun Cao, Hua Huang, Yu-hao Chen, Chen Chen, Pei-jie Chen, Di Wu, Chen Ding, Zi-he Zhang, Rui-hao Zhang, Zi-xuan Hu, Wen-hao Zhao, Ming-hui Liu, Yong-wen Li, Hong-yu Liu, Jun Chen
BE-43547A2 exerts hypoxia-selective inhibition on human pancreatic cancer cells through targeting eEF1A1 and disrupting its association with FoxO1   Pages (1433-1444)
Can Liu, Can Liu, Guang-ju Liu, Meng-meng Wang, Yan Jiao, Yuan-jun Sun, Hui Guo, Liang Wang, Ya-xin Lu, Yue Chen, Ya-hui Ding
Apolipoprotein B100 acts as a tumor suppressor in ovarian cancer via lipid/ER stress axis-induced blockade of autophagy   Pages (1445-1461)
Ze-yuan Yin, Shi-min He, Xin-yuan Zhang, Xiao-chen Yu, Kai-xuan Sheng, Tong Fu, Yi-xue Jiang, Liu Xu, Bing-xuan Hu, Jing-bo Zhang, Yan-yu Li, Qing Wang, Bei-bei Zhang, Yun-meng Qi, Joseph Adu-Amankwaah, Xue-yan Zhou, Qi Qi, Bei Zhang, Cheng-lin Li
MAI-TargetFisher: A proteome-wide drug target prediction method synergetically enhanced by artificial intelligence and physical modeling   Pages (1462-1475)
Shi-wei Li, Peng-xuan Ren, Lin Wang, Qi-lei Han, Feng-lei Li, Hong-lin Li, Fang Bai
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2   Pages (1476-1491)
Cai-ling Tang, Yuan-qing Li, Xi-kun Du, Xiao-xia Fang, Yi-man Guang, Pei-zhuo Li, Shuang Chen, Sheng-yu Xue, Jia-min Yu, Xiao-yi Liu, Yi-pan Luo, Lan-xin Zhou, Cheng Luo, Huan Xiong, Zhong-jie Liang, Hong Ding

Editorial Expression of Concern

Editorial Expression of Concern: The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells   Pages (1492)
Qian-mei Zhou, Song Wang, Hui Zhang, Yi-yu Lu, Xiu-feng Wang, Yoshiharu Motoo, Shi-bing Su

Retraction Note

Retraction Note: Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma   Pages (1493)
Ming-jie Pang, Zhun Yang, Xing-lin Zhang, Zhao-fang Liu, Jun Fan, Hong-ying Zhang

Correction

Correction: Chemokine CCL2 promotes cardiac regeneration and repair in myocardial infarction mice via activation of the JNK/STAT3 axis   Pages (1494)
Wei Wang, Xiao-kang Chen, Lu Zhou, Feng Wang, Yan-ji He, Bing-jun Lu, Ze-gang Hu, Zhu-xin Li, Xue-wei Xia, Wei Eric Wang, Chun-yu Zeng ✉, Liang-peng Li