Vol 43, No 10 (October 2022) - Acta Pharmacologica Sinica

Review Article

Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases Pages (2439–2447) Open

Miao-miao Lin, Na Liu, Zheng-hong Qin, Yan Wang

Connexin 43: insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy Pages (2448–2461)

Ning-ning Zhang, Yi Zhang, Zhen-zhen Wang, Nai-hong Chen

Pyroptosis and pyroptosis-inducing cancer drugs Pages (2462–2473)

Fan Yang, Sahana N. Bettadapura, Mark S. Smeltzer, Hua Zhu, Shanzhi Wang

Current strategies and progress for targeting the “undruggable” transcription factors Pages (2474–2481)

Jing-jing Zhuang, Qian Liu, Da-lei Wu, Lu Tie

Article

Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway Pages (2482–2494)

Jian-mei Gao, Xun Zhang, Guo-tao Shu, Na-na Chen, Jian-yong Zhang, Fan Xu, Fei Li, Yuan-gui Liu, Yu Wei, Yu-qi He, Jing-shan Shi, Qi-hai Gong

FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice Pages (2495–2510) Open

Dan-yang Zhu, Jian Lu, Rui Xu, Juan-zhen Yang, Xiang-rui Meng, Xing-nan Ou-Yang, Qiu-ying Yan, Rui-fang Nie, Tong Zhao, Yi-di Chen, Yin Lu, Yi-nan Zhang, Wen-jun Li, Xu Shen

Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Pages (2511–2526)

Zhou Zhu, Liang-feng Liu, Cheng-fu Su, Jia Liu, Benjamin Chun-Kit Tong, Ashok Iyaswamy, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Xin-jie Guan, Yu-xuan Kan, Wen-jian Xie, Chen-liang Zhao, King-ho Cheung, Jia-hong Lu, Jie-qiong Tan, Hong-jie Zhang, Ju-xian Song, Min Li

Protection against glutathione depletion-associated oxidative neuronal death by neurotransmitters norepinephrine and dopamine: Protein disulfide isomerase as a mechanistic target for neuroprotection Pages (2527–2541)

Hye Joung Choi, Tong-xiang Chen, Ming-Jie Hou, Ji Hoon Song, Peng Li, Chun-feng Liu, Pan Wang, Bao Ting Zhu

IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway Pages (2542–2549)

Shuai-xing Wang, Ye-nan Feng, Shan Feng, Ji-min Wu, Mi Zhang, Wen-li Xu, You-yi Zhang, Hai-bo Zhu, Han Xiao, Er-dan Dong

Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter Pages (2550–2561) Open

Hong-yang Shu, Yi-zhong Peng, Wei-jian Hang, Min Zhang, Lan Shen, Dao-wen Wang, Ning Zhou

Tax1 banding protein 1 exacerbates heart failure in mice by activating ITCH-P73-BNIP3-mediated cardiomyocyte apoptosis Pages (2562–2572)

Qing-qing Wu, Qi Yao, Tong-tong Hu, Ying Wan, Qing-wen Xie, Jin-hua Zhao, Yuan Yuan, Qi-zhu Tang

Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects Pages (2573–2584)

Chao Ye, Zhi Geng, Ling-li Zhang, Fen Zheng, Ye-bo Zhou, Guo-qing Zhu, Xiao-qing Xiong

Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome Pages (2585–2595) Open

Hui Fu, Qi-rui Shen, Yi Zhao, Min Ni, Can-can Zhou, Ji-kuai Chen, Chen Chi, Dong-jie Li, Guang Liang, Fu-ming Shen

Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl⁻ concentration and activation of SGK1 signaling pathway Pages (2596–2608)

Han-yan Yang, Chao Zhang, Liang Hu, Chang Liu, Ni Pan, Mei Li, Hui Han, Yi Zhou, Jie Li, Li-yan Zhao, Yao-sheng Liu, Bing-zheng Luo, Xiong-qing Huang, Xiao-fei Lv, Zi-cheng Li, Jun Li, Zhi-hong Li, Ruo-mei Wang, Li Wang, Yong-yuan Guan, Can-zhao Liu, Bin Zhang, Guan-lei Wang

Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho Pages (2609–2623)

Wei Zhou, Min-min Chen, Hui-ling Liu, Zi-lin Si, Wen-hui Wu, Hong Jiang, Lin-xiao Wang, Nosratola D. Vaziri, Xiao-fei An, Ke Su, Cheng Chen, Ning-hua Tan, Zhi-hao Zhang

Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling Pages (2624–2635)

Ke Lin, Na Yang, Wu Luo, Jin-fu Qian, Wei-wei Zhu, Shi-ju Ye, Chen-xin Yuan, Di-yun Xu, Guang Liang, Wei-jian Huang, Pei-ren Shan

Intramuscular injection of sotagliflozin promotes neovascularization in diabetic mice through enhancing skeletal muscle cells paracrine function Pages (2636–2650)

Lai-liu Luo, Jing-xuan Han, Shou-rong Wu, Vivi Kasim

Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice Pages (2651–2665)

Xin-huang Lv, Xiao-xia Cong, Jin-liang Nan, Xing-mei Lu, Qian-li Zhu, Jian Shen, Bei-bei Wang, Zhi-ting Wang, Ri-yong Zhou, Wei-an Chen, Lan Su, Xiao Chen, Zheng-zheng Li, Yi-nuo Lin

Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown Pages (2666–2677)

Xi-yu Mei, Jing-nan Zhang, Wang-ya Jia, Bin Lu, Meng-na Wang, Tian-yu Zhang, Li-li Ji

CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers Pages (2678–2686)

Jiang-yan Cao, Shuang Qi, Hong Wu, Ao-li Wang, Qing-wang Liu, Xi-xiang Li, Bei-lei Wang, Juan Ge, Feng-ming Zou, Cheng Chen, Jun-jie Wang, Chen Hu, Jing Liu, Wen-chao Wang, Qing-song Liu

The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma Pages (2687–2695)

Jia-hao Liu, Hui-ling Yang, Shu-ting Deng, Zhe Hu, Wei-feng Chen, Wei-wei Yan, Ren-tao Hou, Yong-hao Li, Rui-ting Xian, Ying-ying Xie, Yun Su, Li-yang Wu, Ping Xu, Zhi-bo Zhu, Xiong Liu, Yu-ling Deng, Yu-bing Wang, Zhen Liu, Wei-yi Fang

Pan-KRAS inhibitors suppress proliferation through feedback regulation in pancreatic ductal adenocarcinoma Pages (2696–2708)

Cheng-xiang Wang, Ting-ting Wang, Kun-dong Zhang, Ming-yu Li, Qian-cheng Shen, Shao-yong Lu, Jian Zhang

ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway Pages (2709–2722)

Sha Li, Hong Yang, Wan Li, Jin-yi Liu, Li-wen Ren, Yi-hui Yang, Bin-bin Ge, Yi-zhi Zhang, Wei-qi Fu, Xiang-jin Zheng, Guan-hua Du, Jin-Hua Wang

Population pharmacokinetic and pharmacodynamic analysis of rivaroxaban in Chinese patients with non-valvular atrial fibrillation Pages (2723–2734)

Xiao-qin Liu, Yu-fei Zhang, Hong-yan Ding, Ming-ming Yan, Zheng Jiao, Ming-kang Zhong, Chun-lai Ma

Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia Pages (2735–2748)

Mao-feng Zhang, Xiao-yu Luo, Cheng Zhang, Chao Wang, Xi-shan Wu, Qiu-ping Xiang, Yong Xu, Yan Zhang

Vol 43, No 10 (October 2022): Acta Pharmacologica Sinica

Review Article

Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases Pages (2439–2447) Open

Connexin 43: insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy Pages (2448–2461)

Pyroptosis and pyroptosis-inducing cancer drugs Pages (2462–2473)

Current strategies and progress for targeting the “undruggable” transcription factors Pages (2474–2481)

Article

Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway Pages (2482–2494)

FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice Pages (2495–2510) Open

Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Pages (2511–2526)

Protection against glutathione depletion-associated oxidative neuronal death by neurotransmitters norepinephrine and dopamine: Protein disulfide isomerase as a mechanistic target for neuroprotection Pages (2527–2541)

IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway Pages (2542–2549)

Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter Pages (2550–2561) Open

Tax1 banding protein 1 exacerbates heart failure in mice by activating ITCH-P73-BNIP3-mediated cardiomyocyte apoptosis Pages (2562–2572)

Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects Pages (2573–2584)

Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome Pages (2585–2595) Open

Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl⁻ concentration and activation of SGK1 signaling pathway Pages (2596–2608)

Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho Pages (2609–2623)

Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling Pages (2624–2635)

Intramuscular injection of sotagliflozin promotes neovascularization in diabetic mice through enhancing skeletal muscle cells paracrine function Pages (2636–2650)

Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice Pages (2651–2665)

Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown Pages (2666–2677)

CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers Pages (2678–2686)

The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma Pages (2687–2695)

Pan-KRAS inhibitors suppress proliferation through feedback regulation in pancreatic ductal adenocarcinoma Pages (2696–2708)

ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway Pages (2709–2722)

Population pharmacokinetic and pharmacodynamic analysis of rivaroxaban in Chinese patients with non-valvular atrial fibrillation Pages (2723–2734)

Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia Pages (2735–2748)

Table of Contents

Cover Image

Vol 43, No 10 (October 2022): Acta Pharmacologica Sinica

Review Article

Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases Pages (2439–2447) Open

Connexin 43: insights into candidate pathological mechanisms of depression and its implications in antidepressant therapy Pages (2448–2461)

Pyroptosis and pyroptosis-inducing cancer drugs Pages (2462–2473)

Current strategies and progress for targeting the “undruggable” transcription factors Pages (2474–2481)

Article

Trilobatin rescues cognitive impairment of Alzheimer’s disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway Pages (2482–2494)

FX5, a non-steroidal glucocorticoid receptor antagonist, ameliorates diabetic cognitive impairment in mice Pages (2495–2510) Open

Corynoxine B derivative CB6 prevents Parkinsonian toxicity in mice by inducing PIK3C3 complex-dependent autophagy Pages (2511–2526)

Protection against glutathione depletion-associated oxidative neuronal death by neurotransmitters norepinephrine and dopamine: Protein disulfide isomerase as a mechanistic target for neuroprotection Pages (2527–2541)

IMM-H007 attenuates isoprenaline-induced cardiac fibrosis through targeting TGFβ1 signaling pathway Pages (2542–2549)

Trimetazidine enhances myocardial angiogenesis in pressure overload-induced cardiac hypertrophy mice through directly activating Akt and promoting the binding of HSF1 to VEGF-A promoter Pages (2550–2561) Open

Tax1 banding protein 1 exacerbates heart failure in mice by activating ITCH-P73-BNIP3-mediated cardiomyocyte apoptosis Pages (2562–2572)

Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects Pages (2573–2584)

Activating α7nAChR ameliorates abdominal aortic aneurysm through inhibiting pyroptosis mediated by NLRP3 inflammasome Pages (2585–2595) Open

Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl− concentration and activation of SGK1 signaling pathway Pages (2596–2608)

Dihydroartemisinin suppresses renal fibrosis in mice by inhibiting DNA-methyltransferase 1 and increasing Klotho Pages (2609–2623)

Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling Pages (2624–2635)

Intramuscular injection of sotagliflozin promotes neovascularization in diabetic mice through enhancing skeletal muscle cells paracrine function Pages (2636–2650)

Anti-diabetic drug canagliflozin hinders skeletal muscle regeneration in mice Pages (2651–2665)

Scutellarin suppresses triple-negative breast cancer metastasis by inhibiting TNFα-induced vascular endothelial barrier breakdown Pages (2666–2677)

CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers Pages (2678–2686)

The small molecule chemical compound cinobufotalin attenuates resistance to DDP by inducing ENKUR expression to suppress MYH9-mediated c-Myc deubiquitination in lung adenocarcinoma Pages (2687–2695)

Pan-KRAS inhibitors suppress proliferation through feedback regulation in pancreatic ductal adenocarcinoma Pages (2696–2708)

ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway Pages (2709–2722)

Population pharmacokinetic and pharmacodynamic analysis of rivaroxaban in Chinese patients with non-valvular atrial fibrillation Pages (2723–2734)

Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia Pages (2735–2748)

Table of Contents

Cover Image

Platelet CFTR inhibition enhances arterial thrombosis via increasing intracellular Cl⁻ concentration and activation of SGK1 signaling pathway Pages (2596–2608)