Vol 41, No 5 (May 2020): Acta Pharmacologica Sinica

Review Article

CRISPR-cas9: a powerful tool towards precision medicine in cancer treatment   Pages (583-587)
Hui Xing, Ling-hua Meng

Article

Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation   Pages (588-598)
Wen-xuan Jian, Zhao Zhang, Jia-hong Zhan, Shi-feng Chu, Ye Peng, Ming Zhao, Qi Wang, Nai-hong Chen
DL0410 ameliorates cognitive deficits in APP/PS1 transgenic mice by promoting synaptic transmission and reducing neuronal loss   Pages (599-611)
Wei Zhou, Wen-wen Lian, Rong Yan, Hao Jia, Lv-jie Xu, Lin Wang, Ai-lin Liu, Guan-hua Du
Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways   Pages (612-619)
Xiao Huang, Guo-qiang Fei, Wen-juan Liu, Jing Ding, Yuan Wang, Hao Wang, Jian-lin Ji, Xin Wang
Metoprolol prevents neuronal dendrite remodeling in a canine model of chronic obstructive sleep apnea   Pages (620-628)
Lin Yang, Jing Zhao, Yang Qu, Qiang Sun, Ting-ting Li, Mei-ling Yan, Ming-jing Duan, Ke-xin Li, Yan-ru Wang, Si-yu Huang, Shuai Zhang, Yue Li, Jing Ai
Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels   Pages (629-637)
Zhu-qing Xie, Xiao-ting Tian, Yue-ming Zheng, Li Zhan, Xue-qin Chen, Xiao-ming Xin, Cheng-gang Huang, Zhao-bing Gao
Zinc protects against cadmium-induced toxicity in neonatal murine engineered cardiac tissues via metallothionein-dependent and independent mechanisms   Pages (638-649)
Hai-tao Yu, Juan Zhen, Jian-xiang Xu, Lu Cai, Ji-yan Leng, Hong-lei Ji, Bradley B Keller
Acid sphingomyelinase downregulation alleviates vascular endothelial leptin resistance in rats   Pages (650-660)
Bei-bo Cai, Yi-ni Lu, Ming Xu
A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression   Pages (661-669)
Na Zhang, Shuang-shuang Zhao, Yi-xuan Zhang, Yu-cheng Wang, Rong-guang Shao, Ju-xian Wang, Hong-wei He
Ganoderic acid hinders renal fibrosis via suppressing the TGF- β/Smad and MAPK signaling pathways   Pages (670-677)
Xiao-qiang Geng, Ang Ma, Jin-zhao He, Liang Wang, Ying-li Jia, Guang-ying Shao, Min Li, Hong Zhou, Shu-qian Lin, Jian-hua Ran, Bao-xue Yang
Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice   Pages (678-685)
Pei-pei Zhang, Lin-lin Li, Xue Han, Qin-wei Li, Xu-hua Zhang, Johnson J. Liu, Ye Wang
The novel quinolizidine derivate IMB-HDC inhibits STAT5a phosphorylation at 694 and 780 and promotes DNA breakage and cell apoptosis via blocking STAT5a nuclear translocation   Pages (686-697)
Wu-li Zhao, Yan Xing, Cheng Ye, Yu-han QiuYiLi, Xiu-jun Liu, Meng-yan Wang, Chong-wen Bi, Dan-qing Song, Rong-guang Shao
Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity   Pages (698-705)
Le-le Zhang, Jing Guo, Xiao-ming Jiang, Xiu-ping Chen, Yi-tao Wang, Ao Li, Li-gen Lin, Hua Li, Jin-jian Lu
[1,2,4]Triazolo[1,5-a]pyrimidine derivative (Mol-5) is a new NS5-RdRp inhibitor of DENV2 proliferation and DENV2- induced inflammation   Pages (706-718)
Yi-hong Wan, Wen-yu Wu, Song-xin Guo, Shi-jun He, Xiao-dong Tang, Xiao-yun Wu, Kutty Selva Nandakumar, Min Zou, Lin Li, Xiao-guang Chen, Shu-wen Liu, Xin-gang Yao
PK/PD modeling based on NO-ET homeostasis for improving management of sunitinib-induced hypertension in rats   Pages (719-728)
Hao-chen Liu, Xiao-ting Zhou, Yun-si Zheng, Hua He, Xiao-quan Liu

Publisher Correction

Publisher Correction: Integrating yeast chemical genomics and mammalian cell pathway analysis   Pages (729)
Fu-lai Zhou, Sheena C Li, Yue Zhu, Wan-jing Guo, Li-jun Shao, Justin Nelson, Scott Simpkins, De-hua Yang, Qing Liu, Yoko Yashiroda, Jin-biao Xu, Yao-yue Fan, Jian-min Yue, Minoru Yoshida, Tian Xia, Chad L Myers, Charles Boone, Ming-wei Wang