Yangxin Tongmai Formula ameliorates impaired glucose tolerance in children with Graves’ disease through upregulation of the insulin receptor levels

Yan-hong LUO1, Min ZHU1, Dong-gang WANG1, Yu-sheng YANG1, Tao TAN2, Hua ZHU2, Jian-feng HE1
1 Children’s Hospital Chongqing Medical University, Chongqing 400000, China
2 Department of Surgery, Davis Heart and Lung Research Institute, the Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
Correspondence to: Yan-hong LUO:, Jian-feng HE:,
DOI: 10.1038/aps.2017.94
Received: 8 May 2017
Accepted: 17 June 2017
Advance online: 23 November 2017


Graves’ disease (GD) is the leading cause of hyperthyroidism, and the majority of GD patients eventually develop disorders of glucose handling, which further affects their quality of life. Yangxin Tongmai formula (YTF) is modified from a famous formula of traditional Chinese medicine for the treatment of cardiovascular diseases. In this study we investigated the potential effects of YTF in the treatment of pediatric GD patients with impaired glucose tolerance. Forty pediatric GD patients and 20 healthy children were recruited for this clinical study. Based on the glucose tolerance, the GD patients were divided into two groups: 20 patients displayed impaired glucose tolerance, while the other 20 patients displayed normal glucose tolerance. YTF was orally administered for 60 days. YTF administration significantly ameliorated the abnormal glucose tolerance and insulin sensitivity in the GD patients with impaired glucose tolerance. To determine the molecular mechanisms of this observation, the number of plasma insulin receptors was determined by ELISA. Before treatment, the fasting and postprandial levels of the insulin receptor were significantly lower in patients with impaired glucose tolerance compared with those in patients with normal glucose tolerance and healthy children. After YTF treatment, both the fasting and the postprandial circulating insulin receptor levels were upregulated, and close to those in healthy children. Therefore, YTF is a potential effective treatment to enhance glucose handling in GD children with impaired glucose tolerance.
Keywords: Yangxin Tongmai formula; traditional Chinese medicine; Graves’ disease; impaired glucose tolerance; insulin receptor; insulin resistance; Fangjiomics

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