New omic and network paradigms for deep understanding of therapeutic mechanisms for Fangji of traditional Chinese medicine

Authors: Dayue Darrel Duan1,2, Zhong Wang3, Yong-yan Wang3
1 Center for Phenomics of Traditional Chinese Medicine/the Affiliated Hospital of Traditional Chinese Medicine, Southwest Medical University, Luzhou 646000, China
2 Department of Pharmacology, University of Nevada Reno School of Medicine, Reno, NV 89557, USA
3 Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
Corresponding to: Dayue Darrel Duan: dduan@medicine.nevada.edu, Zhong Wang: zhonw@sina.com, Yong-yan Wang: wangyongyan2010@sina.cn,
DOI: 10.1038/aps.2018.42


Combination therapy with multi-drug regimen as an integrated intervention of several pharmacological compounds that interact with multiple targets, rather than monotherapy using a single compound that targets at a single molecule, is a common strategy for combating complex disease in both Western and traditional Chinese medicine (TCM)[1-3].