Recent advances in peptide nucleic acid for cancer bionanotechnology

Authors: Jun-chen WU, Qing-chun MENG, Hong-mei REN, Hong-tao WANG, Jie WU, Qi WANG
DOI: 10.1038/aps.2017.33


Peptide nucleic acid (PNA) is an oligomer, in which the phosphate backbone has been replaced by a pseudopeptide backbone that is meant to mimic DNA. Peptide nucleic acids are of the utmost importance in the biomedical field because of their ability to hybridize with neutral nucleic acids and their special chemical and biological properties. In recent years, PNAs have emerged in nanobiotechnology for cancer diagnosis and therapy due to their high affinity and sequence selectivity toward corresponding DNA and RNA. In this review, we summarize the recent progresses that have been made in cancer detection and therapy with PNA biotechnology. In addition, we emphasize nanoparticle PNA-based strategies for the efficient delivery of drugs in anticancer therapies.
Keywords: peptide nucleic acids; bionanotechnology; cancer diagnostics and therapy