Therapeutic effects of interleukin-1 receptor antagonist on allergic rhinitis of guinea pig.

AIM: To determine the effect of interleukin-1 receptor antagonist (IL-1ra) on allergic rhinitis. METHODS: Allergic rhinitis was induced by toluene-2,4-diisocyanate (TDI). At the end of the treatment, the pathological changes in the nasal mucosa were observed. The concentrations of histamine in the nasal mucosa and IgE in the blood were determined as well. RESULT: Symptoms of allergic rhinitis were remarkably relieved after IL-1ra treatment. Hematoxylin and eosin staining demonstrated that less edema was found in the nasal mucosa and small vessel was normal after IL-1ra application, but edema,vasodilation, and inflammatory cell infiltration were discovered in the model group. The concentrations of histamine in the nasal mucosa and IgE in the blood were less than those in the control group. CONCLUSION: IL-1ra im administration selectively and non-traumatically alleviated nasal congestion, rhinorrhea, and sneezing.