Original Article

Effects of pokeweed antiviral protein on nephrotoxic serum nephritis accelerated by rabbit IgG in mice

Quan Zhu, Xiao-Dong Li, Geng-Xian Shi


In the mouse model, Pokeweed antiviral protein (PAP) significantly decreased the level of urinary protein excretion, blood urea nitrogen and blood cholesterol (p<0.01), but increased the level of serum albumin (p<0.01) in nephrotoxic serum nephritis accelerated by rabbit IgG. There was no significant difference between the PAP (ip l.5 mg/(kg-d) x14) and cyclophosphamide (ip 10 mg/(kg.d) x14) groups (p>0.05). Peripheral WBC and peritoneal macrophage phagocytosis were decreased to a lesser extent by PAP than by cyclophosphamide (p<0.01). The evidence suggests that PAP may be useful for inhibiting nephritic changes due to less immunosuppression.

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