Effects of azimexon on interleukin 2 and interleukin l production in vitro
Abstract
Azimexon, an immunostimulating agent, did not induce the production of interleukin 2 (IL-2) from murine splenocytes in vitro, but did enhance the secretion of IL-2 from Con A-stimulated splenocytes at an optimal concentration of 0.05 ptg/ml. Azimexon increased the production of interleukin I (IL-I) from murine peritoneal macrophages, with the optimal concentration being 5 yg/ml. Dynamic observation indicated that the optimal pretreatment times for increasing IL-2 and IL-1 were 6 and 16 h, respectively.
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