Antiulcer effects of pirenzepine in rats

Pirenzepine 25, 50, 100 mg/kg ig inhibited the gastric ulcers induced by indomethacin, reserpine, stress and pyloric ligation in rats and showed dose-dependently. Pirenzepine 100 mg/kg ig tended to accelerate the healing of gastric ulcer induced by acetic acid and inhibited the formation of cysteatnine-produced duodenal ulcer in rats. The hexosamine content in gastric tissue of rats was incrcased by this drug in a dose-dependent way. It also stimulated [3H]TdR incoporation into the DNA of gastric mucosal cells of rats given either in vivo (50 mg/kg) or in vitro (10 vg/ml). It is suggested that both the inhibition of gastric acid and pepsin secretion and the increase in resistance of the gastric mucosal barrier to harmful factors may be involved in the antiulcer mechanism of pirenzepine.