Original Article

Effect of histamine H3-receptor antagonist clobenpropit on spatial memory of radial maze performance in rats

Authors: Zhong Chen

Abstract

"AIM:
The effect of histamine H3-receptor antagonist, clobenpropit (VUF9153) on spatial memory deficits induced by scopolamine was investigated in rats.
METHODS:
Eight-Arm radial maze performance was used to measure spatial memory in rats, and the brain regions were subsequently dissected and histamine contents were determined by HPLC.
RESULTS:
Intracerebroventricular (icv) injection of clobenpropit (50 micrograms) ameliorated memory impairment induced by scopolamine in both parameters of radial maze performance. The amelioration induced by clobenpropit was antagonized by an H3-agonist, (R)-alpha-methylhistamine (5-10 micrograms). alpha-Fluoromethylhistidine (10, 20 micrograms), a histidine decarboxylase inhibitor, also effectively reversed clobenpropit-induced ameliorating effects.
CONCLUSION:
The brain histamine H3-receptor antagonists are highly related to the spatial memory, and this action may be due to cholinergic neurons."
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