Original Article

Wound healing activity of human placental extracts in rats

Authors: Tuhin Kanti Biswas, Biswajit Auddy, Nitai P Bhattacharya, Subahshree Bhattacharya, Biswapati Mukherjee

Abstract

Aim: To study wound healing activity of the human placental extract (HPE) in rats.
Methods: Full thickness wounds were inflicted on depilated dorsum of Charles foster rats with 8 mm Acu-punch biopsy. The HPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physical criteria, biochemical criteria, and histopathological study with respect to untreated control, vehicle control (1.5 % benzyl alcohol), and framycetin topical treated groups.
Results: Significant lowering of wound size (P<0.05), wound index (P<0.05), and number of days required for complete healing (P<0.01); significant gain in tensile strength (P<0.01); appreciable increase of tissue DNA, total protein, and collagenesis were observed in HPE treated group.
Conclusion: Human placental extract systematically helps collagenesis leading to potent healing of wounds.
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