Review

Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides

Authors: Jing Xu, Cheng-shi Jiang, Zai-long Zhang, Wen-quan Ma, Yue-wei Guo
DOI: 10.1038/aps.2013.155

Abstract

Jing XU1, 3, #, Cheng-shi JIANG2, #, Zai-long ZHANG1, *, Wen-quan MA3, Yue-wei GUO2, *
1College of Science, China University of Petroleum, Qingdao 266580, China; 2State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; 3Weifang Biomedical Innovation and Entrepreneurship Service Center, Weifang 261205, China

Macrolides, which comprise a family of lactones with different ring sizes, belong to the polyketide class of natural products. Resorcinolic macrolides, an important subgroup, possess interesting structures and exhibit a wide variety of bioactivities, such as anti-tumor, anti-bacteria, and anti-malaria activities, etc. This review summarizes progress in isolation, bioactivity studies, biosynthesis, and representative chemical syntheses of this group of macrolides in recent decades, encompassing 63 naturally occurring macrolides published in 120 articles.


Keywords: natural product; resorcinolic macrolide; fungal metabolite; bioactivity; anti-tumor; anti-bacteria; anti-malaria; biosynthesis

This research work was financially supported by Na­tional Marine ‘863’ Project (Nos 2011AA09070102 and 2013AA092902), the National Natural Science Foundation of China (Nos 81302692, 81273430, and 31070310), SKLDR/SIMM Project (No SIMM1105KF-04), and was partially funded by the EU 7th Framework Programme-IRSES Project (No 246987).
# These authors contributed equally to this work.
* To whom correspondence should be addressed.
E-mail zzlyrs@upc.edu.cn (Zai-long ZHANG); ywguo@mail.shcnc.ac.cn (Yue-wei GUO)
Received 2013-07-13 Accepted 2013-09-25
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