Blood pressure variability is increased in genetic hypertension and L-NAME -induced hypertension
Abstract
Aim: To examine whether the blood pressure variability (BPV) is increased in spontaneously hypertensive rats (SHR) and L-NAME-induced hypertensive rats (NHR).
Methods: BPV was recorded with continuous hemodynamic monitoring in conscious un restrained rats. Time course of L-NAME-induced hypertension was measured by the tail-cuff method. Plasma NO concentration was determined by the method of nitric acid reductase.
Results: In both SHR and NHR, systolic and diastolic BPV were significantly increased when compared with their respective controls. In S HR, in crease in diastolic BPV was predominant, whereas in NHR, increase in systolic BP V was predominant. Moreover, increase in systolic BPV in NHR (102 %) was obviously higher than that in SHR (28 %). Chronic administration of L-NAME 1 g/L in drink ing water caused a progressive increase in arterial blood pressure in rats. All rats were hypertensive at 4 weeks after treatment. Plasma NO level was decreased in NHR.
Conclusion: Increased BPV is a general phenomenon in hypertension. NO is involved in the regulation of BPV.
Keywords:
Methods: BPV was recorded with continuous hemodynamic monitoring in conscious un restrained rats. Time course of L-NAME-induced hypertension was measured by the tail-cuff method. Plasma NO concentration was determined by the method of nitric acid reductase.
Results: In both SHR and NHR, systolic and diastolic BPV were significantly increased when compared with their respective controls. In S HR, in crease in diastolic BPV was predominant, whereas in NHR, increase in systolic BP V was predominant. Moreover, increase in systolic BPV in NHR (102 %) was obviously higher than that in SHR (28 %). Chronic administration of L-NAME 1 g/L in drink ing water caused a progressive increase in arterial blood pressure in rats. All rats were hypertensive at 4 weeks after treatment. Plasma NO level was decreased in NHR.
Conclusion: Increased BPV is a general phenomenon in hypertension. NO is involved in the regulation of BPV.