Determination of arterial baroreflex-blood pressure control in conscious rats.
Abstract
AIM: To study the determination of arterial baroreflex-blood pressure control
(ABR-BP) in conscious rats.
METHODS: Blood pressure was continuously recorded with a computerized system in
conscious freely moving rats. The principle of ABR-BP measurement is to compare
the pressor response to a vasoactive drug (angiotensin II) before and after the
interruption of this reflex.
RESULTS: (1) ABR-BP values revealed by angiotensin II were closely correlated
with those by phenylephrine. Doses of angiotensin II did not influence the
results within certain range. (2) ABR-BP was well correlated with arterial
baroreflex-heart period control (ABR-HP). (3) Anesthesia inhibited ABR-BP. There
existed a circadian variation of ABR-BP in WKY rats. (4) Blood pressure
variability was closely related to ABR-BP, but not to ABR-HP. (5) ABR-BP was
impaired in hypertensive rats.
CONCLUSION: ABR-BP is an important parameter to reflect the function of ABR. The
present work makes it possible to determine ABR-BP in conscious rats. ABR-BP
plays an important role in maintaining blood pressure stability and it is
impaired in hypertension.
Keywords:
(ABR-BP) in conscious rats.
METHODS: Blood pressure was continuously recorded with a computerized system in
conscious freely moving rats. The principle of ABR-BP measurement is to compare
the pressor response to a vasoactive drug (angiotensin II) before and after the
interruption of this reflex.
RESULTS: (1) ABR-BP values revealed by angiotensin II were closely correlated
with those by phenylephrine. Doses of angiotensin II did not influence the
results within certain range. (2) ABR-BP was well correlated with arterial
baroreflex-heart period control (ABR-HP). (3) Anesthesia inhibited ABR-BP. There
existed a circadian variation of ABR-BP in WKY rats. (4) Blood pressure
variability was closely related to ABR-BP, but not to ABR-HP. (5) ABR-BP was
impaired in hypertensive rats.
CONCLUSION: ABR-BP is an important parameter to reflect the function of ABR. The
present work makes it possible to determine ABR-BP in conscious rats. ABR-BP
plays an important role in maintaining blood pressure stability and it is
impaired in hypertension.