Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats.
Abstract
AIM: To investigate whether or not brain histamine was involved in memory
deficits induced by lesions of nucleus basalis magnocellularis (NBM) in rats.
METHODS: Passive avoidance response was used to measure memory process in rats,
and NBM was bilaterally lesioned by injection of ibotenic acid (6 microg/site).
RESULTS: Icv injection of histamine (500 ng), and ip injection of histidine (1500
mg/kg), metoprine (10 mg/kg) or tacrine (3, 5 mg/kg) ameliorated memory
impairment induced by NBM lesion regarding passive avoidance response. The
ameliorating effect of histidine was antagonized by pyrilamine (2-5 mg/kg), a
H1-antagonist, but not by zolantidine, a H2-antagonist.
CONCLUSION: Histaminergic neurons play an important role in learning and memory
via H1-receptor, and its action may be due to cholinergic neurons.
Keywords:
deficits induced by lesions of nucleus basalis magnocellularis (NBM) in rats.
METHODS: Passive avoidance response was used to measure memory process in rats,
and NBM was bilaterally lesioned by injection of ibotenic acid (6 microg/site).
RESULTS: Icv injection of histamine (500 ng), and ip injection of histidine (1500
mg/kg), metoprine (10 mg/kg) or tacrine (3, 5 mg/kg) ameliorated memory
impairment induced by NBM lesion regarding passive avoidance response. The
ameliorating effect of histidine was antagonized by pyrilamine (2-5 mg/kg), a
H1-antagonist, but not by zolantidine, a H2-antagonist.
CONCLUSION: Histaminergic neurons play an important role in learning and memory
via H1-receptor, and its action may be due to cholinergic neurons.