Effects of new constituents L-6a and L-10 from leaves of Luffa cylinderica on learning, memory, and hippocampal somatostatin in rats
Abstract
AIM: To study the effects of two constituents L-6a and L-10 from the leaves of
Luffa cylinderica Roem on learning, memory, and hippocampal somatostatin in rats.
METHODS: The learning and memory in rats were determined using the passive
avoidance response of shuttle-box, by i.c.v. Somatostatin in hippocampus was
determined with immunohistochemical and images analyses.
RESULTS: L-6a 25 micrograms raised memory-keeping activity (P < 0.05) in rats.
L-6a 25 micrograms increased the surface density and number density of
somatostatin-like immureactant (Som-LI) (P < 0.05). L-10 25 and 50 micrograms
increased the surface density and number density of Som-LI (P < 0.05).
CONCLUSION: L-6a 25 micrograms enhanced memory-keeping activity and increased the
surface density and number density of Som-LI in rats. L-10 shows a tendency to
enhance memory-keeping activity but no evident, but it increases the surface
density and number density of Som-LI.
Keywords:
Luffa cylinderica Roem on learning, memory, and hippocampal somatostatin in rats.
METHODS: The learning and memory in rats were determined using the passive
avoidance response of shuttle-box, by i.c.v. Somatostatin in hippocampus was
determined with immunohistochemical and images analyses.
RESULTS: L-6a 25 micrograms raised memory-keeping activity (P < 0.05) in rats.
L-6a 25 micrograms increased the surface density and number density of
somatostatin-like immureactant (Som-LI) (P < 0.05). L-10 25 and 50 micrograms
increased the surface density and number density of Som-LI (P < 0.05).
CONCLUSION: L-6a 25 micrograms enhanced memory-keeping activity and increased the
surface density and number density of Som-LI in rats. L-10 shows a tendency to
enhance memory-keeping activity but no evident, but it increases the surface
density and number density of Som-LI.