Modulation of phosphatidylinositol turnover on central nicotinic receptors
Abstract
AIM: To study the modulatory effects of phosphatidylinositol (PI) turnover on
nicotinic receptors in CNS, and to study the relationship between brain nicotinic
receptors and PI turnover.
METHODS: Effects of inositol phosphatase inhibitor lithium chloride (LiCl) and
muscarinic receptor agonist oxotremorine (Oxo) on nicotine-induced convulsions
were investigated in mice.
RESULTS: The effects of nicotine for producing convulsions were modified by LiCl
2.5-10 mmol.kg-1, revealing the convulsive effects of nicotine > 0.8 mg.kg-1 were
increased by acute pretreatment with LiCl rather than oxotremorine. Mice were
given LiCl 5.0 mmol.kg-1 once a day for 7 d, the ED50 value of nicotine for
producing convulsions was increased from 0.58 to 0.97 mg.kg-1, suggesting that
the sensitivity of central nicotinic receptors for mediating convulsions was
decreased by chronic treatment with LiCl.
CONCLUSION: The functions of central nicotinic receptors were modulated by PI
turnover.
Keywords:
nicotinic receptors in CNS, and to study the relationship between brain nicotinic
receptors and PI turnover.
METHODS: Effects of inositol phosphatase inhibitor lithium chloride (LiCl) and
muscarinic receptor agonist oxotremorine (Oxo) on nicotine-induced convulsions
were investigated in mice.
RESULTS: The effects of nicotine for producing convulsions were modified by LiCl
2.5-10 mmol.kg-1, revealing the convulsive effects of nicotine > 0.8 mg.kg-1 were
increased by acute pretreatment with LiCl rather than oxotremorine. Mice were
given LiCl 5.0 mmol.kg-1 once a day for 7 d, the ED50 value of nicotine for
producing convulsions was increased from 0.58 to 0.97 mg.kg-1, suggesting that
the sensitivity of central nicotinic receptors for mediating convulsions was
decreased by chronic treatment with LiCl.
CONCLUSION: The functions of central nicotinic receptors were modulated by PI
turnover.