Hippocampal non-NMDA and GABA-A receptors in benzylpenicillin-induced epilepsy and electro-acupuncture antiepilepsy
Abstract
AIM: To study the effect of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and
bicuculline (Bic) on benzyl-penicillin-induced-epilepsy (PIE) and
electroacupuncture (EA) antiepilepsy in rats.
METHODS: Epilepsy was elicited by intra-hippocampal microinjection of
benzylpenicillin in rats. The analysis of electroencephalogram (EEG) and power
spectrum was used to measure the extent of convulsion.
RESULTS: EA or DNQX (1 microgram) showed partial inhibitory effect on PIE. EA +
DNQX caused further inhibition of PIE, and Bic attenuated EA antiepileptic
effect.
CONCLUSION: Antagonization of GABA-A receptor attenuated EA antiepileptic effect,
and EA acted synergistically with the antagonists of non-N-methyl-D-aspartate
(non-NMDA) receptors.
Keywords:
bicuculline (Bic) on benzyl-penicillin-induced-epilepsy (PIE) and
electroacupuncture (EA) antiepilepsy in rats.
METHODS: Epilepsy was elicited by intra-hippocampal microinjection of
benzylpenicillin in rats. The analysis of electroencephalogram (EEG) and power
spectrum was used to measure the extent of convulsion.
RESULTS: EA or DNQX (1 microgram) showed partial inhibitory effect on PIE. EA +
DNQX caused further inhibition of PIE, and Bic attenuated EA antiepileptic
effect.
CONCLUSION: Antagonization of GABA-A receptor attenuated EA antiepileptic effect,
and EA acted synergistically with the antagonists of non-N-methyl-D-aspartate
(non-NMDA) receptors.