Adrenoceptor agonists inhibit calcium-dependent potentials in rat stellate ganglion neurons
Abstract
AIM: To study the effects of adrenoceptor agonists on the stellate ganglion
neurons.
METHODS: Intracellular recordings were made from neurons of the isolated rat
stellate ganglia.
RESULTS: Noradrenaline and clonidine (10-30 mumol.L-1) reversibly depressed 3
types of calcium-dependent potentials, namely, the action potential shoulder; the
spike after-hyperpolarization; the Ca2+ spike evoked in Krebs' solution
containing TTX and TEA and fast excitatory postsynaptic potential (f-EPSP).
CONCLUSION: The adrenoceptor agonists inhibitied the 3 calcium-dependent
potentials; f-EPSP was inhibited by reducing Ca2+ influx at presynaptic site in
population of neurons.
Keywords:
neurons.
METHODS: Intracellular recordings were made from neurons of the isolated rat
stellate ganglia.
RESULTS: Noradrenaline and clonidine (10-30 mumol.L-1) reversibly depressed 3
types of calcium-dependent potentials, namely, the action potential shoulder; the
spike after-hyperpolarization; the Ca2+ spike evoked in Krebs' solution
containing TTX and TEA and fast excitatory postsynaptic potential (f-EPSP).
CONCLUSION: The adrenoceptor agonists inhibitied the 3 calcium-dependent
potentials; f-EPSP was inhibited by reducing Ca2+ influx at presynaptic site in
population of neurons.