Original Articles

8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate actions on calcium dynamics in cultured vascular smooth muscle cells.

Shirley X L Liu, George C Y Chiou, Zhou Chen


AIM: To study 8-(N,N-Diethylamino)n-octyl-3,4,5-trimethoxybenzoate (TMB), a
potent Ca(2+)-antagonist, actions on cellular calcium dynamics in vascular smooth
muscle cell (VSMC) cultures.
METHODS: A7r5 VSMC were cultured with Fura-2 measurements of intracellular Ca2+
concentration, [Ca2+]i.
RESULTS: TMB reduced [Ca2+]i from control levels and blocked [Ca2+]i increase
caused by norepinephrine (NE) and 2,5-di (t-butyl)-1,4-benzohydroquinone (BHQ).
[Ca2+]i reduction by TMB was further enhanced by ryanodine.
CONCLUSION: TMB is an effective agent for blocking the [Ca2+]i increase caused by
NE and BHQ and for enhancing the [Ca2+]i reduction caused by ryanodine.

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