Original Article

Genetic polymorphism of 4'-hydroxylation of S-mephenytoin in 148 Chinese of Han nationality

Zou-Rong Ruan, Yuan-Shen Cheng, Jun-Fu Zhou, Yi Zhao, Yi-Zheng Pan, De-Yun Ding


To study genetic polymorphism of S-mephenytoin (S-Mep) 4'-hydroxylation in the Chinese population of Han nationality.

The lg metabolic ratio (MR) and lg hydroxylation index (HI) in the urine (0-12 h) after oral administration with 100 mg of racemic Mep tablet were determined by HPLC method in 148 consangeously unrelated native Chinese subjects and 21 individuals of 5 families.

The lg MR and lg HI showed a bimodal distribution with an antimode of -1.00 and 1.50, respectively. The occurrence of poor metabolizers (PM) was 13.5% in the population. The pedigree analysis in 5 families indicated that deficient S-Mep hydroxylation was an autosomal recessive trait.

The occurrence of PM for S-Mep 4-hydroxylation in Chinese was higher than that of the Caucasians, and both genetic modes were of autosomal recessive trait.

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