Original Articles

Inhibition of bone marrow immature B lymphocytes from zinc deficient mice by methionine enkephalin

Gang Li, Jie Yu


Bone marrow cells (BMC) from Zn deficient mice were used to measure the anti-TNP plaque forming cell (PFC) response in the presence of methionine enkephalin (Met-Enk). The results demonstrated that the PFC response of BMC was suppressed by Met-Enk. In the case of Zn deficient group, the inhibitions were up to 51% compared to 27% for the control and became higher as the increasing concentration of Met-Enk. It seems that the sensitivity to Met-Enk was related to degree of Zn deficiency. These findings suggest that Zn may interfere with the role of Met-Enk on BMC.

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