Anti-ulcer activity of Na-gamma-hydroxybutyrate in rat stomach

The antigastric ulcer activity of Na-gamma-hydroxybutyrate (GHBA) was studied on various experimental ulcers in rats. The results showed that the number of gastric ulcers induced by sc indomethacin 20 mg/kg, restraint stress or pyloric ligation were markedly diminished by GHBA. Pretreatment with GHBA 10 mg/kg im bid 5 times revealed significant anti-ulcer activity in all of these models. The inhibitory rates of ulcer were 42, 71 and 51% for indomethacin, restraint stress and pyloric ligation, respectively. Chronic gastric ulcer induced by 10% acetic acid was also inhibited by GHBA 10 mg/kg im bid for 8 days. The ulcer inhibitory rate was 73%. The amount of gastric mucus glycoprotein and [3H] TdR incorporation into gastric tissues was increased by GHBA, but the volume of gastric juice, and acid and pepsin output were not influenced. It is suggested that the prevention of GHBA on gastric mucosal damage may be related to its preservation of the gastric mucosal barrier.