Effects of harmine on immune function of mice
Abstract
The effects of harmine (Har) on immune systems in normal mice were studied. At the sc doses of 16 or 25 mg/(kg·d) ×7 d, Har decreased the thymus and spleen weights of mice, the immune specific rosette forming cells, the antibodies and the delayed hypersensitivity in footpad of mice induced by sheep red blood cells. Meanwhile there were no marked potentiating effects of Har on the phagocytoses of monomacrophage systems in mice. Har 30, 37 or 47 μg/ml suppressed lymphocyte transformation of [3H]TdR incorporation induced by PHA in vitro.
Keywords: