Original Articles

Induction of drug-metabolizing enzymes in rat liver by hexachloro-p-xylene

Authors: Ping Yi, Yu-Zhu Quan

Abstract

Hexachloro-p-xylene (HCX), a useful drug for the treatment of clonorchiasis in China, is similar to DDT in chemical structure, physicochemical properties and disposition in the body. Since DDT is a well known hepatic microsomal drug-metabolizing enzymes inducer, the effects of HCX on the activities of hepatic drug-metabolizing enzymes were investigated.
Hypnotic time induced by sodium pentobarbital was significantly shortened in rats pretreated with ig HCX 100 or 150 mg/kg, qd×6 d. However, the rat brain pentobarbital concentration during awakening did not change significantly after the pretreatment with HCX. The key component enzyme of the hepatic microsomal drug-metabolizing enzyme system (cytochrome P-450), the microsomal marker enzyme (cytochrome B5) as well as the representative drug-metabolism activities (pentobarbital side chain hydroxylase and aminopyrine N-demethylase) were increased in the rat liver homogenates. Since the liver weight of the rats treated with HCX was increased while the SGPT level still maintained in a normal range, the increase of liver weight may be the result of increases in the enzymes and the smooth endoplasmic reticulum.
The above results suggest strongly that HCX is an inducer of drug-metabolizing enzymes in rat liver.
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