Original Article

Circadian effect on gastrodin pharmacokinetics in rats

Chang-wei LU, Yuan-jie ZOU, Qi-zhong MO, Jian HUANG, De-quan CHU, De-yong YE


Circadian fluctuations of pharmacokinetic parameters of [3H]gastrodin; Maximal time to reach peak (1.12 h) and the maximal absorption rate constant (4 h-1) appeared when [3H]gastrodin (18.5 MBq/kg) was given intragastrically at 08:00 and 20:00. The area under the plasma radioactivity curve (AUC) was found to be lowest (143*103 cpm/ml.h) when [3H]gastrodin was given at 02:00.

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