Original Article

Effects of etorphine and electro-acupuncture on electroconvulsive shock in rats

Xiao-ping HE, Xiao-ding CAO


Seizures were induced by electroconvulsive shock (ECS) in 75 rats. Etorphine (ip) decreased seizure duration, its ED(50) being 11 microg/kg. Etorphine (icv) facilitated seizures with ED(50) 0.35 microg. These effects of etorphine were in a dose-dependent manner. Electroacupuncture (EA) inhibited partially the seizures; this inhibitory effect was reversed by ip naloxone. These results suggest that EA exerts the anticonvulsive action via endogenous opioid system.

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