Original Article

Influence of hypothalamic arcuate nucleus lesion with monosodium glutamate on plasma corticosterone in neonatal rats

Hui-ci LIU, Qi-liang CHEN, Feng GU


The purpose of present experiment was to assess the role of hypothalamic arcuate nucleus (ARC) in regulation of pituitary-adrenocortical system. The plasma corticosterone was determined by competitive protein-binding radioassay. The number of ARC neurons in monosodium glutamate (Msg)-treated rats showed a decrease of 60%, and the pituitary gland in Msg-treated group was smaller than that of control group (P<0.01), but there was no obvious difference in the weights of adrenal glands. No significant difference in corticosterone levels was seen between Msg-treated group and the control one, even after electrical foot-shock. These results indicate that the neurons in ARC do not play an essential role in the regulation of pituitary-adrenocortical system.

Article Options

Download Citation

Cited times in Scopus