Effects of acute ammonia poisoning on cerebral amino acids metabolism in rats
Abstract
Acute ammonia intoxication was produced by ip ammonium acetate 0.45 g/kg in rats. After 15 min, the concentrations of Asp, Glu and Ser of the brain were reduced, GABA, Ala, Gly unchanged, and Gln increased. A fall in the activities of GOT and glutaminase in the brain along with a rise in that of glutamine synthetase and GDH was seen. No change was observed in the activity of GPT. The change in the concentration of Asp was negatively correlated with the level of brain ammonia after ammonia intoxication. The concentration of Asp and Glu returned to normal when the brain ammonia level reduced.
Keywords: