The in vivo disposition of diethyllipoamide (author's transl)
Abstract
The total radioactivities in plasma and bone marrow after im injection of [35S]diethyllipoamide were closely related to the radioprotective effects. Analysis of blood samples with paper radiochromatography and scanning showed that the active form of the drug in vivo was diethyllipoamide per se. The drug passed rapidly into the brain and was mainly distributed in liver and kidney. About 53% of the radioactivities was excreted in urine within 24 h. The characteristics of distribution of the drug in these tissues were believed to be responsible for the transient toxic signs after large doses.
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