Tranquillizine effects of total alkaloids of corydalis saxicola
Abstract
Subcutaneous injections of the total alkaloids 10-70 mg/kg decreased strikingly the caffeine-induced hyperactivity of mice, produced taming effects in monkeys and cats, induced catalepsy in monkeys, cats and rats, inhibited the aggressive behavior of mice induced by electrical foot shocks, blocked the avoidance responses of rats, but exerted little influence on their escape responses.
The alkaloids 25 mg/kg prolonged the hypnotic time of pentobarbital in mice, increased the analgesic effect of pethidine, but did not induce sleep by doses up to 100 mg/kg.
The alkaloid antagonized the hyperactivity and fighting behavior of mice induced by amphetamine, but did not protect the mice from death.
The cerebral-electrical activity of rabbits was depressed by iv 20-30 mg/kg.
The acute sc LD50 of the total alkaloids in mice was 0.22 g/kg.
Keywords:
The alkaloids 25 mg/kg prolonged the hypnotic time of pentobarbital in mice, increased the analgesic effect of pethidine, but did not induce sleep by doses up to 100 mg/kg.
The alkaloid antagonized the hyperactivity and fighting behavior of mice induced by amphetamine, but did not protect the mice from death.
The cerebral-electrical activity of rabbits was depressed by iv 20-30 mg/kg.
The acute sc LD50 of the total alkaloids in mice was 0.22 g/kg.