Effects of intracoronary injections of sodium tanshinone II-A sulfonate and dipyridamole on myocardial infarct size in acute ischemic dogs
Abstract
Determinations of epicardial electrogram and femoral arterial blood pressure were made after ligation of LAD. The myocardial infarct size was measured by N-BT technique at 24 h after LAD occlusion. In dogs with 1 mg/kg of sodium tanshinone II-A sulfonate or dipyridamole injected into the distal end of LAD beyond occlusion, the sizes of acute myocardial infarcts were significantly reduced, but neither epicardial S-T segment nor blood pressure showed significant changes.
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