Original Articles

Central depressive action of propranolol

Yin-quan Pei, Hai-yan Yao, Zhi-lin Zhang


Studies were carried out on the central depressive action of propranolol in mice and rats. Propranolol was found to markedly antagonize maximal electroshock seizures in mice (ED50=7 mg, sc) and audiogenic seizures in rats. It could also protect mice from the tonic seizure induced by iv pentylenetetrazol 40 mg/kg, but not from the clonic seizure by sc 85 mg/kg.
Propranolol exhibited some synergistic actions when it was used in combination with Phenobarbital or diphenylhydantoin. Reserpine markedly reduced its anticonvulsant effects. Besides, propranolol could prevent tremor in mice induced by arecoline.

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