Beyond iron deposition: making sense of the latest evidence on ferroptosis in Parkinson’s disease

Hai-ying Zhu1, Qiao-jun He1,2,3, Bo Yang1,2, Ji Cao1,2,3
1 Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2 Innovation Institute for Artificial Intelligence in Medicine, Zhejiang University, Hangzhou, China
3 Cancer center of Zhejiang University, Hangzhou, China
Correspondence to: Ji Cao:,
DOI: 10.1038/s41401-020-00555-7
Received: 28 July 2020
Accepted: 8 October 2020
Advance online: 19 November 2020


Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Here, we suggest that beyond iron deposition, emerging evidence further supports the involvement of ferroptosis in PD. A detailed understanding of ferroptosis in PD will help to predict the onset and progression of disease and establish personalized treatments.

Article Options

Download Citation

Cited times in Scopus