Vol 47, No 10 (October 2026): Acta Pharmacologica Sinica

Review Article

Fibroblast growth factors in ischemic stroke: Therapeutic potential and clinical challenges   Pages (2695-2708) Open
Confidence Dordoe, Kai-ming Guo, Canol Bwalya, Wen-ting Huang, Shi-hao Chen, Jun Chen, Xue Wang, Peng Wang, Xiao-kun Li, Lin Li
Sweetening the bonds: how O-GlcNAcylation modulates cell adhesion   Pages (2709-2721)
Wen-hui Lou, Guo-hong Qiao, Zi-jun Wei, Yu-qin Hu, Yang Li, Qi-jie Zhao, Shi-sheng Zhou, Yue Wang, Bei Chen, Zhi-wei Xu, Xiang Chen
Advancing PROTAC therapeutics through chemistry-guided design of smart delivery systems   Pages (2722-2744) Open
Ting-ting Yao, Zheng Zhou, Guang-ji Wang, Zhe-ying Zhu, Xi-nuo Li
Adenosine receptor signaling in vascular diseases: from molecular mechanisms to targeted therapeutics   Pages (2745-2760)
De-hua Yang, Jiao-jiao Wang, Yu-qing Huo, Zhi-ping Liu
Recent advances in the development of GRK2 inhibitors: blocking the interaction of GRK2 with its partners   Pages (2761-2776) Open
Chen-chen Han, Hao-zhou Guo, Fu-yuan Guo, Hong-zheng Tan, Hua-zhan Sun, Jin-tao Gu, Shu-jun Zuo, Wei-kang Wang, Yang Ma, Wei Wei
RNA m6A methylation writers in autoimmune diseases: structure, function, and therapeutic opportunities   Pages (2777-2790)
Xue-feng Gao, Gao-na Shi, Ya-nan Wang, Bo Zhang, Li Li, Tian-tai Zhang
Beyond conventional therapies: the evolution of targeted agents and immunotherapies in triple-negative breast cancer   Pages (2791-2819)
Hui-fang Cheng, Yan-mei Chen, Pei-yan Liu, Xin Jin, Yi Qu, Bo Liu, Ai-zhuo Li

Article

Amyloid-beta fibrils as active contributors to synaptic dysfunction in Alzheimer’s disease   Pages (2820-2828) Open
Nunzia Maisto, Giorgia Ciufolini, Sepideh Dashtiani, Lorenzo Casoli, Almerinda Di Venere, Marilena Carbone, Dalila Mango
Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits   Pages (2829-2846) Open
Bai-hui Chen, Ye-ru Chen, Liang-yu Zheng, Hua-jing Cai, Xin-long Ke, Shi-yu Li, Zheng-jie Chen, Xiang-nan Zhang, Feng-quan Zhou, Gang Chen
DNMT1-mediated central amygdala to locus coeruleus circuit contributes to chronic pain-related depression in mice   Pages (2847-2861)
Xiao-bao Ding, Xin-yu Li, Yi-yuan Zhang, Meng-yuan Zhou, Yu-wen Lin, Wen-li Hu, Xiang-li Wu, Rui Li, Yao-long Zhuang, Cheng-hua Zhou, Yu-qing Wu
Clemastine alleviates cognitive dysfunction after SAH by targeting neuronal CNTN1 to regulate the ADA-adenosine pathway   Pages (2862-2878) Open
Long-xiang Li, Bo-yang Wei, Lei Jin, Yu Wu, Ze-yu Yang, Can Li, Jia-ming Zhou, Yu Song, Wen-zhi Gong, Yuan-hao Ou-Yang, Hao Huang, Xin Feng, Shen-quan Guo, Wen-ping Cheng, Ran Li, Shu-yin Liang, Shi-xing Su, Fa Jin, Xin Zhang, Yan-chao Liu, Chuan-zhi Duan, Wen-chao Liu, Xi-feng Li
Peripheral somatostatin-expressing neurons are analgesic targets for refractory occipital neuralgia   Pages (2879-2891)
Qiong Wang, Chen Li, Qian-wen Zhu, Teng-fei Liu, Guo-dun Zhao, Yi-fan Tang, Ye Jiang, Zi-xian Chen, Jing Feng, Yong Yu, Zhao-bing Gao
GATA3 drives chronic stress-induced depressive-like behaviors by reducing hippocampal CA3 pyramidal neuronal activity in male mice   Pages (2892-2907)
Yi-qin Yao, Zhi-yi Xu, Bo-wei Guo, Cun Wang, Hao Hong, Zhi-gang Chen, Su-su Tang
ATF3/SOX11-regulated FST activates IGF1R–ERK/ AKT–Sp1 signaling to sustain trigeminal neuropathic pain   Pages (2908-2923)
Yue-juan Ling, Bing Zhu, Zuo-hao Yao, Ling-jie Ma, Lin-peng Zhu, Jing Zhang, Fei-fei Xu, Hao Wu, Lu-lu Ji, Yong-jing Gao
Endothelial PARP1 orchestrates endothelial-to-mesenchymal transition via the PARylation of FHL2 in ischaemic heart failure   Pages (2924-2939)
Lin-jie Su, Yu He, Zhuo-jun Wang, Jia-qi Lan, Wen-wei Luo, Ru-yao Mo, Shi-yi He, Pei-qing Liu, Jian-wen Chen, Zhuo-ming Li
Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG   Pages (2940-2954) Open
Nina E. Ottosson, Damon J. A. Frampton, Tanadet Pipatpolkai, Caitlyn Norman, Urban Karlsson, Amaia Jauregi-Miguel, Maryke Venter, Akshay Sridhar, H. Peter Larsson, Henrik Gréen, Sara I. Liin
KCNE2 upregulation improves cardiac function by inhibiting Smurf1-mediated SERCA2a degradation in diabetic cardiomyopathy in mice   Pages (2955-2968)
Ming Song, Kai-ping Gao, Jie Yang, Yu-qi Tu, Yi-xin Zhu-Ge, Wan-wen Cheng, Gang Wang, Ying Li, Wen-juan Liu, Jie Liu
miR-203 improves pressure overload-induced heart failure by targeting the IGFBP5/PI3K/AKT axis   Pages (2969-2982)
Ping-ping Tang, Run Xu, Song Wang, Wei-yi Zhang, Xin-xin Dong, Li-na Yao, Ling-yi Kong, Chang Mao, Yu-dong Bao, Hui-qian Tang, Dian-ya Sun, Ning Wang, Xin Liu, Yong Zhang
A dual-antigen mRNA-lipid polyplex vaccine elicits durable multistage immunity and sterile protection against malaria in mice   Pages (2983-2995) Open
Xiaoxing Wang, Aiai Wang, Wenqi Huang, Penghai Tian, Long Cao, Bo Xiao, Jipin Han, Zhenghui Huang, Lubin Jiang
BMAL1 silencing as a promising chemosensitizing strategy for triple-negative breast cancer   Pages (2996-3008)
Lu-yi Wang, Xue-han Xu, Wen-jing Xuan, Xin-yue Bi, Qin Zhou
Penfluridol directly targets PDPK1 to suppress AKT1 phosphorylation and stabilize CTR1, inducing cuproptosis in colorectal cancer   Pages (3009-3023)
Ke-min Ni, Hua-qing Wang, Xiao-fei Shi, Qing Yu, Xin-tong Dai, Ji-yan Wang, Ming-ming Sun, Qi Yan, Xin-ru Zhai, Yan-fei Liu, Kai-long Zhao, Wan-ting Wang, Meng-wei Fu, Xiao-tong Wang, Shi-yu Fang, Jie Zhang, Hua-miao Wang, Chang-liang Shan, Shuai Zhang, Chun-ze Zhang
Targeting BCL9/BCL9L enhances CD4+ T cell-mediated Th1 antitumor immunity through activation of STAT1/STAT4 signaling   Pages (3024-3041)
Yuan-yuan Zhu, An-qi Li, Fan Yang, Yu-xuan Dong, Ya-si Huang, Xiang-jing Meng, Dai-zhou Zhang, Ye Li, Yan-fang Xian, Di Zhu, Mei Feng
Visible light reprograms MSCs and T cells into tumor- suppressive states via OPN4-mediated epigenetic remodeling   Pages (3042-3058) Open
Yin-zhi Xu, Zhao-yuan Xu, Uma K. Aryal, Andy Chen, Sungsoo Na, Hiroki Yokota
Development of XYD113 as a potent and highly selective GSPT1 degrader for cancer therapy   Pages (3059-3068)
Hui Shen, Xiao-yu Luo, Xin-yi Jing, Wei-qin Jin, Hong-rui Xu, Jian-kang Hu, Zhi-xin Zhong, Jian Zhang, Hao-zhao Liang, Xiao-xi Zhuang, Hong-hua Ge, Jeff B. Smaill, Jin-xin Xu, Yan Zhang, Adam V. Patterson, Jin-ming Ma, Yong Xu
Targeting USP8 with odoroside A regulates LXRβ-mediated fatty acid metabolic reprogramming against colorectal cancer   Pages (3069-3082)
Yan-yan Chen, Fang-fang Liu, Shi-yuan Wen, Xiao-han Song, Zi-han Ye, Chun-cao Xu, Yan-bei Tu, He Huang, Jin-jian Lu
Targeting JOSD2 degrades β-catenin to suppress colorectal cancer metastasis by disrupting RAS/ERK/β-catenin axis   Pages (3083-3095)
Yue Liu, Shu-yu Yang, Wen-han Zhang, Yan-ting Liang, Jun-wei Fu, Jing-yu Dai, Rui-lin Wu, Chu-run Zheng, Hao-tong Wang, Yong-hao Li, Run-qiu Guo, Chen-ming Zeng, Xiang-yu Xu, Zheng-bo Song, Chun-wei Xu, Ji Cao, Qiao-jun He, Hong Zhu, Tao Yuan, Bo Yang

Correction

Correction: Myeloid-derived growth factor suppresses VSMC dedifferentiation and attenuates postinjury neointimal formation in rats by activating S1PR2 and its downstream signaling   Pages (3096-3097)
Shuang Yang, Hou-wei Li, Jia-ying Tian, Zheng-kai Wang, Yi Chen, Ting-ting Zhan, Chun-yue Ma, Min Feng, Shi-feng Cao, Yu Zhao, Xue Li, Jing Ren, Qian Liu, Lu-ying Jin, Zhi-qi Wang, Wen-yu Jiang, Yi-xiu Zhao, Yan Zhang, Xue Liu
Correction: Codelivery of dihydroartemisinin and doxorubicin in mannosylated liposomes for drug-resistant colon cancer therapy   Pages (3098)
Xue-jia Kang, Hui-yuan Wang, Hui-ge Peng, Bin-fan Chen, Wen-yuan Zhang, Ai-hua Wu, Qin Xu, Yong-zhuo Huang