Vol 47, No 9 (September 2026): Acta Pharmacologica Sinica

Research Highlight

Pulsatile FXR activation: Timing bile acid-targeted therapy to physiology   Pages (2299-2302)
Ting-ying Jiao, Yang-tai Li, Frank J. Gonzalez, Cen Xie

Review Article

Nanoparticles for autoimmune diseases: advancing diagnostics and therapeutic solutions   Pages (2303-2322) Open
Elaine Xue Ning Ong, Chester Yan Jie Ng, Lu-lei Cao, Xuexin Li, Pan P. Li, Nguan Soon Tan, Zehuan Liao, Yan Zhao
Cell-based cancer immunotherapy: milestones, mechanistic insights, and emerging therapeutic directions   Pages (2323–2340)
Ji-zhao Cao, Wei Zhao, Xiao-jun Xia
Echoes in the powerhouse: mito-lncRNAs contribution to cardiac function and disease   Pages (2341-2357) Open
Abdallah Iddy Chaurembo, Na Xing, Zi-feng Huang, Baraka Simon Mayamba, Francis Chanda, Yun-tao Liang, Yong-fang Lin, Wen-hui Deng, Jian-yuan Huang, Zeng-yu He, Zheng Tan, Chi Shu, Han-bin Lin

Article

PACSIN2-mediated synaptic injury contributes to behavioral disorders caused by chronic stress   Pages (2358-2376) Open
Chang-min Wang, Ye Li, Yu-hang Yi, Xiao Chen, Tian Lan, Hai-yan Lou, Wen-cheng Jian, Mei-jian Wang, Shu-yan Yu
G protein-coupled receptor 75 mediates depression-like behaviors and HPA axis hyperactivity through an excitatory arcuate-paraventricular nucleus circuit   Pages (2377-2391)
Hao Wang, Yi-hong Wei, An-qi Gao, Juan-juan Guo, Xin Ding, Jing-jing Yang, Zi-ru Wang, Jun-cheng Da, Yue Kang, Jian-hua Ding, Yi Fan, Ming Lu, Li Zhang, Gang Hu
Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation   Pages (2392-2408)
Fang-fang Gao, Yi-fan Xu, Jing Zhang, Shi-meng Qu, Fan Xiao, Jin-qian Cheng, Zhuo-qin Yuan, Guang-ji Wang, Meng-jie Yu, Ji-ye Aa
The multilevel exploration test, a novel paradigm to measure exploratory behavior in depression animal models and the involvement of the PL-ZI circuit   Pages (2409-2420)
Jun-nan Xu, Jing-ting Li, Ru-xia Xu, Yun-feng Wang, He-wei Gao, Hao-tian He, Han Guo, Yu Liang, Yong-dan Zhu, Xiao-wen Li, Jian-ming Yang, Xiao-ming Li, Yi-hua Chen, Tian-ming Gao
Trim47 protects against hypoxic–ischaemic brain injury in neonatal rats by reducing brain microvascular endothelial inflammation and BBB disruption by interacting with ZO1   Pages (2421-2436)
Xiao-hui Kong, Zu-bin Zhang, Yu Kong, Da-man Tu, Qian-qian Li, Chen-xi Feng, Xin Ding, Li-xiao Xu, Gen Li, Tao Pan, Zheng-hong Qin, Bin Sun, Xing Feng, Mei Li
TIGAR overexpression alleviates intracerebral hemorrhage injury in mice by suppressing ATF4/NOX4/p22phox-mediated oxidative stress and inflammation   Pages (2437-2452)
Yan-yan Li, Jian-rong Yuan, Jie Tang, Lei Chen, Jun-chao Wu, Zheng-hong Qin, Rui Sheng
ApoE impairs microglial efferocytosis by targeting Gas6/ MerTK in a mouse model of acute seizure   Pages (2453-2466)
Bo Gao, Si-min Cheng, Yu-yan Zhang, Hui-xia Yang, Ming-ming Hu, Yu Wang, Jian-ming Han, Li Yu, Shun-zhi Cao, Kun Dong, Hua Kong, Wen-ning Wu
Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility   Pages (2467-2478)
Cong Wang, Ping-chuan Yuan, Qian Sun, Michael Lazarus, Wei-min Qu, Zhi-li Huang, Feng-fei Ding
The solute carrier transporter SLCO5A1 as a novel therapeutic target for the treatment of myocardial infarction-induced heart failure   Pages (2479-2492) Open
Ke-yu Liu, Ke Gong, Fang Fang, Qing-hua Chen, Jin-rong Xu, Liang-qing Zhang, Wen-liang Chen
Resibufogenin promotes angiogenesis via the VAV3-mediated ITGA5–VEGF signaling axis in macrophages to alleviate myocardial infarction   Pages (2493-2509)
Ran Wang, Guo-qiang Lin, Fei-yun Wang, Yao Chen, Shou-jiao Peng, Jian-ge Zhang
TGF-β2 signaling promotes cardiac fibrosis in arrhythmogenic right ventricular cardiomyopathy mediated by DSC2 deficiency   Pages (2510-2524)
Chen-xing Huang, Ke-jia Jin, Lan-qing Xiang, Zhuo-xin Lv, Ying Wang, Jian-guo Jia, Fei-zhen Wu, Yi-zhun Zhu, Yun-zeng Zou, Yu-xiang Dai, Hui Gong
S1UTRSP5, a short restructured RNA from SLIT1 3′UTR, mitigates mouse cardiac remodeling via enhancing SlRT1 activity   Pages (2525-2538)
Jin-feng Su, Tao Ou, Xiao-yao Liu, Xue-min Su, Ya Wang, Yi-hong Wen, Yuan Gao, Ruo-han Li, Lu-fang Huang, Chuan-meng Zhou, Heng-li Zhao, Jie-ning Zhu, Ning Ma, Xi-long Zheng, Yu-peng Liu, Jin-dong Xu, Hui Li, Xian-hong Fang, Zhi-xin Shan
Serum/glucocorticoid-regulated kinase 1 regulates vascular inflammation in atherosclerosis   Pages (2539-2553)
Yang-xian Li, Shu-xiang Ding, Hui-ling Hong, Xiao-yun Cao, Yu-meng Han, Jin-wei Tian, Sin-hang Fung, Stephen Kwok-Wing Tsui, Ya-lan Wu, Xiao Yu Tian
CYFIP2 deficiency ameliorates renal interstitial fibrosis through attenuating tubular senescence in hypertensive nephropathy   Pages (2554-2568) Open
Ming-chen Sun, Fu-wen Zuo, You-zhao Wang, Xiu-li Ren, Hong-shen Lu, Ming-bo Zheng, Hao-ran Zhang, Han-lin Liu, Cui-cui Lu, Cheng-wu Shen, Ji-chao Wu
Few-shot learning-driven discovery of Lutein suppresses Th1- mediated inflammation via glucose metabolism   Pages (2569-2584)
Li-jun Yang, Zong-hui Wei, Pei-jian Cao, Zhi-bin Li, Xiang Li, Jun-wei Zhao, Yi-wen Du, Ke-han Wang, Qiao-hong Zheng, Qiao-jun He, Bo Yang, Jia-jia Wang, Qin-jie Weng
Deficient chaperone-mediated autophagy drives multiorgan fibrogenesis via SMAD2/4 stabilization to sustain TGFβ-SMAD signaling   Pages (2585-2602)
Jia-yuan Jin, Yu-xuan Song, Jia-bin Lu, Guan-qun Li, Jun-qiang Wang, Xue-jing Feng, Pei-hua Luo, Bo Yang, Zhi-fei Xu, Hao Yan, Qiao-jun He, Xiao-chun Yang
PGK1 epigenetically silences STING via DNMT1 and its knockdown synergizes with STING agonists in pancreatic cancer   Pages (2603-2618)
Wan-mei Liu, Jia-hui Xu, Chun-yong Ding, Ao Zhang
6 METTL16 S-glutathionylation-triggered RNA m A modification of IGF2BP3 inhibits CFTR expression and promotes chemoresistance in colorectal cancer   Pages (2619-2637)
Lu Xu, Yan Ma, Wang Yao, Ya-ju Qiu, Chao Xu, Fang-yue Xu, Zhi-miao Zou, Wu-min Dai, Wan-gang Gong, De-ning Ma, Xiao-wan Chen, Wen-kai Ye, Yi-yun Huang, Hai-tao Chen, Lue Hong, Jia-ping Mo, Jian-guo Feng, En-yan Yu, Wei Chen, Yu-hua Zhang, Qing-hua Yao, Xia Li
CCS facilitates the progression of ovarian cancer by suppressing ferroptotic cell death via the modulation of p53- mediated expression of SLC7A11 and GPX4   Pages (2638-2652)
Qi Yan, Ming-ming Sun, Xin-ru Zhai, Hong-kai Chang, Xin-yue Geng, Xiao-bo Zhai, Chen-xin Yang, Yan-ping Li, Tao Wang, Jian-guo Zhao, Tao He, Chang-liang Shan, Shuai Zhang
Time-resolved proteomic and phosphoproteomic analysis reveals convergent and divergent biological perturbations induced by FDA-approved CDK4/6 inhibitors in hormone receptor-positive breast cancers   Pages (2653-2667)
Shi-yu Duan, Lin-hui Zhai, Wei Zhang, Luo-yi Chen, Rui-xi Zhao, Xun Zou, Jia-hui Ni, Xing-long Jia, Tian-yu Liu, Hang Fu, Min Huang, Min-jia Tan, Cheng-yu Chu, Yi-ting Jin
Sirolimus potentiates oncolytic Virus M1 efficacy through tumor-selective augmentation of viral replication   Pages (2668-2681)
Jie-hong Chen, Hong-hui Li, Chao-xin Chen, Cai-xin Yan, Xuan-ming Liang, Cui Guo, Yu Han, Yun-hua Tang, Ying Liu, Jing Cai, Yuan Lin, Jian-kai Liang, Jun Hu, Guang-mei Yan, Jing-jie Li, Wen-bo Zhu
Metabolic checkpoint blockade of IL4I1 by ZY-MY-111 + reactivates CD8 T cell immunity and suppresses tumor growth   Pages (2682-2691)
Ju-fei Li, Hao Wang, Ling Kang, Cheng-cheng Xu, Yuan-chun Liu, Zi-xuan Li, Shao-hao Lin, Ming-zhi Wang, Xiao-min Xu, Pei-pei Wang, Wan-chao Yin, Yu-bo Zhou, Yu Zhou, Jia Li

Correction

Correction: Magnolin overcomes EGFR TKI resistance in NSCLC by modulation of NDRG1–NRG2–HECW1 pathway   Pages (2692-2693)
Qing Wu, Qi Su, Man Zhu, Tian-feng Yang, Wen-juan Tang, Yu Hu, Jia-yan Ren, Xiu-hong Peng, Su-yu Zhang, Yan-min Zhang
Correction: Inhibition of AXL enhances chemosensitivity of human ovarian cancer cells to cisplatin via decreasing glycolysis   Pages (2694)
Min Tian, Xi-sha Chen, Lan-ya Li, Hai-zhou Wu, Da Zeng, Xin-luan Wang, Yi Zhang, Song-shu Xiao, Yan Cheng