Vol 47, No 8 (August 2026): Acta Pharmacologica Sinica

Review Article

Nanobody-based targeted cancer therapy and immunotherapy: fear not the future   Pages (1995-2022)
Ma-di Guo, Ran Liao, Meng-yao Wang, Li-jing Wu, Yong Zhang
Gut microbiota and renal fibrosis: novel mechanistic insights and therapeutic potential   Pages (2023-2034)
Li-min Liu, Xiao-fei He, Yu-lu Zhang, Jing-teng Zhou, Hua Miao, Ying-yong Zhao

Article

TNF-α/PAD4 axis drives hyperhomocysteine-induced white matter injury after acute ischemic stroke   Pages (2035-2048)
Wei-hong Du, Hui Guo, Yi-hui Wang, Xiao-yan Hu, Jia-ning Zhang, Chun Guo, Pan-pan Geng, Yu-ji Wang, Xin-chun Jin
Microglial NLRP3-dependent pyroptosis promotes cognitive dysfunction of diabetic encephalopathy by inhibiting adult hippocampal neurogenesis through the release of IL-1β   Pages (2049-2064) Open
Meng-yu Hua, Shan Huang, Zi-yun Zhuang, Xiao-lin Han, Xiao-jing Liu, Zhong-hao Liang, Neng-jun Lou, Feng-jie Zheng, Li lv, Xiang-hua Zhuang, Shu-yan Yu, Shi-hong Chen
MCOLN1-mediated PPP3CB activation alleviates neuronal damage by promoting TFEB-dependent autophagic flux in permanent cerebral ischemia   Pages (2065-2082)
Shi-qi Liu, Yue-yang Liu, Xiao-xiao Fu, Pei-rui Cui, Xin Wang, Sai-qian Wang, Chun-fu Wu, Li-hui Wang, Jing Luo, Jing-yu Yang
Astrocytic apelin mediates cortical neuronal function and prevents anxiety-like behaviors in mice   Pages (2083-2093)
Xi Luo, Yu-ran Pei, Wei Yu, Ye-lin Dai, Zi-wei Xiong, Yan-bin Jia, Li Zhang, Bo-rui Zhang
Aldose reductase inhibition suppresses microglial endoplasmic reticulum stress and ferritinophagy in ischemic stroke   Pages (2094-2111)
Xing-xing Tu, Fu-lan Luo, Ting-wei Deng, Jia-hui Li, Jia-kang Wang, Jiang-ping Xu, Hai-tao Wang
Non-telomeric function deficiency of TERT enhances pressure overload-induced mouse cardiac remodeling by activation of CNBP-mediated THBS3/ITGB1 pathway   Pages (2112-2129) Open
Ying-ying Liu, Ying-chao Wang, Wen-yan Gong, Hui Luo, Jing-hua Yuan, Zhen Chen, Xiao-ling Xu, Jing Yang, Yu-sheng Cong, Xing-wei Zhang, Qi-bin Jiao
FLRT2 promotes foam cell formation and atherosclerosis by inhibiting USP22-mediated ABCA1 deubiquitination   Pages (2130-2143)
Jing-quan Zhou, Hui-xuan Zhang, Li-zhen Guo, Jie Wang, Yan-yu Chen, En-dong Jiang, Juan Peng, Hong Gao, Yuan-hong Sun, Ming-yan Zhu, Jian-ye Peng, Gao-feng Zeng, Yuan-ye Dang, Kong-yang Ma, Xiao-yan Dai
Intracellular LRG1 recruits MARCH2 to ubiquitinate and degrade endothelial VE-cadherin in septic lung injury   Pages (2144-2159)
Xiao-wei Fang, Jia-ji Fu, Yi-ren Zhang, Yue Zhao, Yang Qiu, Xi Zhou, Ding-yu Zhang, Ji-qian Xu, You Shang
FPR2/ALX stimulation modulates microglia and natural killer cells to restrict autoimmune astrocytopathy   Pages (2160-2170)
Cai-yun Qi, Li-xiang Chen, Yi-wei Fu, Peng-xu Wang, Wei Zhang, Ya-li Han, Tong-xiao Xu, Yuan Li, Xiao-zhen Wang, Gui-yun Cui, Hao Chen, Ming-Wei Wang, Qiang Liu
A novel CDK8/19 inhibitor RO8323 mitigates allograft rejection through dual mechanisms of action to modulate regulatory T cell and myeloid cell   Pages (2171-2181) Open
Fang Shen, Rou Xie, Ye Gan, Ping Ren, Ran-ran Wu, Jia-wei Yan, Yu-ying Bian, Cheng-cheng Liu, Song Yang, Xin-chun Han, Chen-gang Zhou, Yao Wu, Yang Tang, Zhi-heng Xu, Jun Yang, Hong-xia Qiu, Ju-hao Yang, Xue-yan Pu, Li Li, Yue Gui, Gu-liang Xia, Kara G. Lassen, Hong C. Shen, Hao-chu Huang, Lue Dai
5-OH-TMT mitigates colitis through HTRA2 binding–mediated activation of the Dectin-1 signaling pathway   Pages (2182-2195)
Chun-xiu Xiao, Wen-yuan Wu, Shi-cong Li, Mei-ling Dong, Yu-hang Bian, Meng Yu, Xiang Lv, Wei-guo Chen, Min Hong, Jing Zhou, Yang Sun, Hong-yue Ma, Yu-yu Zhu
Fangchinoline restores TFEB-driven lysosomal biogenesis and blocks H1N1 infection   Pages (2196-2208)
Cui-qin Cheng, Fang Xie, Zhe Liu, Jun-liang Li, Yuan-yuan Qiao, Ling-dong Kong, Qi-qi Li, Ke-xin Ma, Fei Liu, Liang-dong Song, Han Wang, Yao Wang, Xin Jia
ADT-OH promotes mitophagy and suppresses the cytosolic mtDNA-cGAS-STING inflammatory cascade in microglia   Pages (2209-2223)
Xiao-ou Hou, Miao Wang, Rong Deng, Yi-fan Lu, Jin-ru Zhang, Li Ren, Jing Chen, Chun-feng Liu, Ya-ping Yang, Li-fang Hu
Piroctone olamine promotes BECN1 transcription and activates autophagy by targeting HDAC6 in colorectal cancer   Pages (2224-2239) Open
Cui-yun Cui, Qiu-tong Li, Xiong-yan Xiang, Ting-yu Fu, Cun-quan Kong, Lu Yu, Wei-dong Ni, Zi-long Zhao, Huai Liu, Qing-chun Zhao, Cui-xia Ma, Lin Chen, Jing-li Shi, Qi Xie, Xiao-ya Sun, Zhi-xiang Xu, Bei-zhan Yan, Yong-ping Jian
Alkalization of the intracellular pH reprograms TNF-α signaling from inflammatory NF-κB activation to tumoricidal RIP kinase-dependent necroptosis in cancer cells   Pages (2240-2253) Open
Chang Ying, Di Wang, Si-ying Zeng, Cheng-meng Jin, Min-feng Ying, Xun Hu
Pharmacological strategies to enhance the response of hepatoblastoma to chemotherapy through MDR1 inhibition   Pages (2254–2267)
Candela Cives-Losada, Rocio I. R. Macias, Elisa Lozano, Laura Zanatto, Pau Sancho-Bru, Maria Luz Martinez-Chantar, Matias A. Avila, Carolina Armengol, Stefano Cairo, Jose J. G. Marin, Oscar Briz
Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model   Pages (2268-2281)
Jun-sheng Xue, Wei-zhe Jian, Zhu-jun Jiang, Tian-yu Wang, Qi-rui Yang, Qing-yu Yao, Tian-yu Bao, Lei Cai, En-ze Gan, Chen Liu, Tian-yan Zhou
Transcutaneous allicin oleogel restores energy homeostasis for obesity treatment   Pages (2282-2296)
Quan-gang Xu, Ze-yun Gu, Wen-jie Chen, Han Liu, Ze-yu Li, Wen-li Cai, Jing Huang, Bahtiyor Muhitdinov, Er-gang Liu, Haji Akber Aisa, Yong-zhuo Huang

Correction

Correction: Berberine attenuates ischemia reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation   Pages (2297-2298)
Jun-rong Zhu, Hai-dan Lu, Chao Guo, Wei-rong Fang, Hong-dong Zhao, Jun-shan Zhou, Feng Wang, Yan-li Zhao, Yun-man Li, Ying-dong Zhang, Yong-zhuo Huang, Jian-guo Sun