Vol 47, No 6 (June 2026): Acta Pharmacologica Sinica

Review Article

ER-phagy receptors: structural mechanisms in selective ER degradation and disease implications   Pages (1385-1400)
Wen-jing Yang, Rui Sheng
Epigenetic regulation and posttranslational modifications of FXR: underlying mechanisms and implications in digestive diseases   Pages (1401-1421)
Qian-rui Mi, Cai-qian Wu, Cheng-guo Lv, Ke-er Zhao, Zhao-feng Liu, Peng-fei Xu, Ling Li
Rebalancing the inflammatory trajectory from inflammatory bowel disease to colitis-associated colorectal cancer via artemisinin-based multitarget therapy   Pages (1422-1435)
Shi-jun He, Mei-lin Tang, Li Chen, Jian-ping Zuo, Han-chen Xu, Ze-min Lin

Article

Discovery of non-opioid peptides that selectively relieve mechanical pain in rodents through inhibition of TRPV4 channels   Pages (1436-1453)
Ping Dong, Qing-ke Fan, Shao-xi Ke, Jia-qi Wang, Yi Mei, Yi-tong Ding, Jing Wang, Jie Xu, Nan Zhou, Yuan-yuan Xu, Jing-jing Wang, Chen Chen, Xiao-hui Wang, Meng Cui, Yi-mei Du, Masahiro Sokabe, Ming-xi Tang, Zhe Zhang, Qiong-yao Tang
Chronic 5-HT7R activation drives depressive phenotypes and synaptic dysfunction   Pages (1454-1470)
Bartłomiej Pochwat, Julia Masternak, Bartosz Bobula, Krystian Bijata, Barbara Chruścicka-Smaga, Justyna Turek, Adam Hogendorf, Maria Walczak, Magdalena Smolik, Remigiusz Worch, Magdalena Kusek, Andrzej J. Bojarski, Krzysztof Tokarski, Bernadeta Szewczyk, Monika Bijata
Status epilepticus-induced 12/15-lipoxygenase drives neuroinflammation and contributes to neuronal injuries and behavioral comorbidities   Pages (1471-1487) Open
Md. Asaduzzaman Rakib, Eun Bee Cho, Nelufar Yasmen, Chenyao Jiang, Md. Aktaruzzaman, Juqian Han, Ying Yu, Jianxiong Jiang
A modified tail suspension test for the assessment of behavioral despair in mice after stroke   Pages (1488-1500)
Pei-ran Kong, Lu Gan, Jia-li Zhang, Long Lin, Hai-yin Wu, Yu-hui Lin, Dong-ya Zhu, Lei Chang, Chun-xia Luo
PDE4 inhibitor rolipram dynamically regulates the balance between D1-MSNs and D2-MSNs in the DMS to modulate abnormal “Go” behavior associated with alcohol addiction   Pages (1501-1516)
Wei Zhao, Shuang Zhao, Zi-qi Wang, Xiao-fei Chen, Fang-jiao Zong, Han-ting Zhang
MPTP and rotenone cause dopaminergic neuronal death by increasing DDIT4 promoter lactylation   Pages (1517-1532)
Jing-chao Hong, Yu-shu Yang, Si-han He, Juan-juan Huang, Xin-rui Zhang, Fang-fang Zeng, Jie-qiong Tan, Hai-long Han, Zhuo-hua Zhang
A novel superior colliculus circuit mediates visual cue-driven methamphetamine taking and seeking   Pages (1533-1545)
Xing-fang Cun, Man-yi Jing, Meng-die Yang, Ning Wu, Jin Li, Rui Song
Inhibition of STING pathway attenuates experimental abdominal aortic aneurysm progression   Pages (1546-1560)
Yu-xin Chen, Chen-rui Shen, Fang-fang Xu, Chen-jun Han, Yu-jie Xi, Yu Shi, Yu-ping Xu, Dong-jie Li, Jian Zhou, Fu-ming Shen, Hui Fu
Histone methyltransferase G9a drives vascular smooth muscle cell proliferation and intimal hyperplasia in mice   Pages (1561-1577)
Si-tong Liu, Shao-wei Liu, Shi-yi He, Zhuo-jun Wang, Mei-ting Chen, Ya-ni Shi, Si-dong Cai, Yan-qi Mai, Pei-qing Liu, Ming-yuan Fan, Rui-ming Liu, Yan Duan, Zhuo-ming Li
Indoleacrylic acid mitigates vascular rarefaction and enhances ischemia-induced neovascularization in aging via APLNR signaling   Pages (1578-1593)
Jun-yu Chen, Ming-hong Chen, Yu Liu, Mei-lian Yao, Xue-rui Wang, Jing Chen, Jian Zhang, Miao Pan, Ji-peng Zhou, Yong-ping Bai
Discovery of vasodilatory effects of Na+/H+ exchanger 1 inhibitors to treat vasospastic angina   Pages (1594-1604)
Xue-fei Dong, Xue-jiao Jing, Zhen-yu Tang, Sheng-lan Huang, Jia-ze Yin, Yuan Chen, Tao Guo, Bo Dong, Bin Li, Peng Li, Shuang-xi Wang, Wen-wu Bai
Triptolide derivative STP1 ameliorates murine systemic lupus erythematosus via targeting Fyn kinase   Pages (1605-1616)
Qiao-yi Ding, Yu Zhou, Hao-wen Luo, Ya-zi Wei, Yi-fan Feng, Dong-ming Zhang, Lei Wu, Cheng-juan Chen, Ying-da Zang, Tian-tai Zhang
Oridonin exerts dual therapeutic effects in MASLD mice by integrating lipid homeostasis and drug bioactivation via the LXRα–CES1/CES2 pathway   Pages (1617-1628)
Huan-guo Jiang, Zhi-kun Zhan, Ling-min Tian, Yu-lian Chen, Mei-qun Cai, Guang-bo Ge, Xin Chen, Chuan-liang Wei, Lan Tang
Asiatic acid promotes CD8+ T cell-mediated antitumor immunity by targeting HDAC8/CXCL10 axis in hepatocellular carcinoma   Pages (1629-1642)
Yu-chuan Chen, Xue-lian Gao, Ge Zeng, Kai-kai Zhang, Chang Yuan, Chang-hao Cheng, Jia-yuan Wan, He-qi Zhou, Zhi-xian Lan, De-kai Zheng, Qiu-hong You, Jian Sun
Epigenetic regulation of NDGA and its synergistic inhibition with EZH2 inhibitors in prostate cancer via NRP1   Pages (1643-1659)
Shuai-shuai Liu, Yuan-ru Wang, Si-meng Gu, Yu-qian Li, Yan-rong Li, Nan-nan Zhang, Lu Tie, Bao-xue Yang, Yan Pan, Xue-jun Li
CSF1R inhibitor C19 for glioma immunotherapy enabled by brain-targeting liposomal delivery   Pages (1660-1670)
Wen-qin Song, Yue-qian Wu, Quan-feng Zhu, Xing-ping Xia, Rui Wang, Lu Yang, Li-hong Hu, Jun-wei Wang, Yong-zhuo Huang, Hui-yuan Wang
Molecular basis for cross-activation of NPFF2R by a short PrRP-related peptide   Pages (1671-1681)
Xin Li, Shuai Li, Hong Shan, Qing-ning Yuan, Xin-heng He, Qian He, Min Zhang, Yang Li, Wen Hu, Kai Wu, H. Eric Xu, Li-hua Zhao
VsNsbench: evaluating AlphaFold3-embed induced-fit mechanism for enhanced virtual screening   Pages (1682-1691)
Shu-kai Gu, Chao Shen, Yu-wei Yang, Si-long Zhai, Jing Li, Ya-nan Tian, Xu-jun Zhang, Hong-yan Du, Zhen-xing Wu, Xiao-rui Wang, Jing-xuan Ge, Hui-feng Zhao, Yuan-sheng Huang, Gao-qi Weng, Huan-xiang Liu, Ting-jun Hou, Yu Kang

Correction

Correction: Deguelin inhibits growth and prolactin synthesis in prolactinomas by targeting the PI3K/AKT/CREB3L1 pathway and ornithine decarboxylase   Pages (1692-1694) Open
Lei Gong, Chang-xiao-feng Liu, Jian-hua Cheng, Jing Guo, Bin Li, Hong-yun Wang, Meng Liu, Jia-lin Wang, Xue-jing Li, Qiu-yue Fang, Zhao-yi Yi, Chu-zhong Li, Ya-zhuo Zhang, Wei-yan Xie